Company Name: |
LGM Pharma
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Tel: |
1-(800)-881-8210 |
Email: |
inquiries@lgmpharma.com |
Products Intro: |
Product Name:Ditazole CAS:18471-20-0 Purity:Typically NLT 98%
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Company Name: |
Energy Chemical
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Tel: |
021-58432009 400-005-6266 |
Email: |
marketing1@energy-chemical.com |
Products Intro: |
Product Name:Ditazole CAS:18471-20-0 Purity:NULL Package:10mg;20mg;2mg;5mg Remarks:NULL
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Company Name: |
Hubei Nordina Biotechnology Co., Ltd.
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Tel: |
19371278702 |
Email: |
nuodinashengwu@163.com |
Products Intro: |
Product Name:Ethanol,2,2'-[(4,5-diphenyl-2-oxazolyl)imino]bis- CAS:18471-20-0
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| ditazole Basic information |
Product Name: | ditazole | Synonyms: | 2,2'-[(4,5-Diphenyl-2-oxazolyl)imino]bisethanol;Agerophas;Apt-574;Diethamphenazole;S-222;ditazole;ditazol;2-[(4,5-diphenyl-1,3-oxazol-2-yl)-(2-hydroxyethyl)amino]ethanol | CAS: | 18471-20-0 | MF: | C19H20N2O3 | MW: | 324.37 | EINECS: | 242-353-5 | Product Categories: | | Mol File: | 18471-20-0.mol | ![ditazole Structure](CAS/GIF/18471-20-0.gif) |
| ditazole Chemical Properties |
Melting point | 100-101°C | Boiling point | 505.5±60.0 °C(Predicted) | density | 1.237±0.06 g/cm3(Predicted) | storage temp. | Refrigerator | solubility | Chloroform (Slightly), Methanol (Slightly) | form | Solid | pka | 14.08±0.10(Predicted) | color | White to Off-White |
| ditazole Usage And Synthesis |
Originator | Ageroplas,Serona,Italy,1973 | Uses | Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation. | Definition | ChEBI: Ditazole is a member of 1,3-oxazoles. | Manufacturing Process | A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams
diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The
solvent was stripped at 1 mm and the oily residue was added at 60°C to 100
ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β-
hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The
product crystallized from ethyl ether + petroleum ether, with a MP of 96 to
98°C. | Therapeutic Function | Antiinflammatory | Trade name | Ageroplas (Lepori, Spain;
Serono, Italy), Fendazol (Lepori, Portugal). | Mechanism of action | Ditazole is an anti-inflammatory analgesic
agent that is of interest primarily for its ability to inhibit platelet aggregation. For example,
it normalizes the enhanced platelet activity in
cerebrovascular patients suffering transient ischemic attacks. | Synthesis | ditazole is prepared by heating 2-
chloro-4,5-diphenyloxazole and diethanolamine
in ethanol.
![ditazole synthesis ditazole synthesis](/NewsImg/2024-03-16/6384619333632596708068127.png) |
| ditazole Preparation Products And Raw materials |
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