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| | (R)-3-Benzyloxy-Pyrrolidine Hydrochloride Basic information |
| Product Name: | (R)-3-Benzyloxy-Pyrrolidine Hydrochloride | | Synonyms: | (R)-3-Benzyloxy Pyrrolidine Hcl;(3R)-3-(benzyloxy)pyrrolidine hydrochloride;(3R)-3-benzyloxypyrrolidine;3-phenylmethoxypyrrolidine hydrochloride;(R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE | | CAS: | 927819-90-7 | | MF: | C11H16ClNO | | MW: | 213.71 | | EINECS: | | | Product Categories: | | | Mol File: | 927819-90-7.mol |  |
| | (R)-3-Benzyloxy-Pyrrolidine Hydrochloride Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature |
| | (R)-3-Benzyloxy-Pyrrolidine Hydrochloride Usage And Synthesis |
| Uses | (R)-3-Benzyloxy-Pyrrolidine Hydrochloride is an important organic reagent that can be used as a building block for the synthesis of many organic compounds, such as (R)-ethyl 4-(3-(benzyloxy)pyrrolidin-1-yl)butanoate.
| | Synthesis | After N-tert-butoxycarbonyl-(R)-3-benzyloxypyrrolidine separately obtained was dissolved in isopropanol and heated to 40 °C, isopropanol solution of hydrogen chloride was dropped for 6 hours. After the reaction finished, the mixture was cooled to 23 °C and was concentrated to distil the solvent away. Further, ethyl acetate was added and the mixture was concentrated, thereby obtaining a concentrate in an amount of about. Then, the concentrate was heated to 40 °C, and isopropanol was added until (R)-3-benzyloxypyrrolidine hydrochloride which had been separated as an oily substance became completely dissolved. After (R) -3-benzyloxypyrrolidine hydrochloride was crystallized by gradually cooling the solution and suitably adding a seed crystal, hexane was further added. At the time, crystallization solvent was in a following proportion: isopropanol/ethyl acetate/hexane = 1/71.5/71.5. A deposited crystal was subjected to filtration under reduced pressure, and the resultant wet crystal was washed with ethyl acetate, and then a wet crystal was dried under reduced pressure, thereby obtaining dry crystal of (R)-3-benzyloxypyrrolidine hydrochloride (yield of 82 %, purity of 99.8 %).
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| | (R)-3-Benzyloxy-Pyrrolidine Hydrochloride Preparation Products And Raw materials |
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