阿替美唑盐酸盐
中文名称 | 阿替美唑盐酸盐 |
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中文同义词 | 阿替美唑盐酸盐(标准品);阿替美唑盐酸盐;4-(2-乙基-2-茚满)咪唑盐酸盐;化合物ATIPAMEZOLE HYDROCHLORIDE;4-(2-乙基-2,3-二氢-1H-茚-2-基)-1H-咪唑盐酸盐;优选]ATIPAMEZOLE HYDROCHLORIDE |
英文名称 | Atipamezole hydrochloride |
英文同义词 | 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride;Atipamezole HCL;4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride;4-(2-Ethyl-2-indanyl)imidazole hydrochloride;Atipamezole hydrochloride;Antisedan;MPV 1248 hydrochloride;MPV1248 hydrochloride |
CAS号 | 104075-48-1 |
分子式 | C14H16N2.HCl |
分子量 | 248.75 |
EINECS号 | 105-700-9 |
相关类别 | 其他科研原料药;原料药;烯烃;医药原料;原料;API |
Mol文件 | 104075-48-1.mol |
结构式 |
阿替美唑盐酸盐 性质
熔点 | 211-215° |
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储存条件 | Sealed in dry,Room Temperature |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
颜色 | 白色至类白色 |
Merck | 14,861 |
InChI | InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H |
InChIKey | PCCVCJAQMHDWJY-UHFFFAOYSA-N |
SMILES | C1(CC)(CC2=C(C=CC=C2)C1)C1=CNC=N1.Cl |
CAS 数据库 | 104075-48-1(CAS DataBase Reference) |
Target | Value |
α2 adrenergic receptor
() |
The affinity of atipamezole for α 2 -adrenoceptors and its α 2 /α 1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α 2 -adrenoceptors. It has negligible affinity for 5-HT 1 , 5-HT2 and I2 bindings sites.
Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory.
安全信息
RTECS号 | NI6139000 |
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海关编码 | 2933.29.2000 |
毒性 | LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin) |