- ADRENORPHIN
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- $7.00 / 1KG
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2020-02-19
- CAS: 88377-68-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | ADRENORPHIN Basic information |
| Product Name: | ADRENORPHIN | | Synonyms: | H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2;METORPHIN;METORPHINAMIDE;METORPHAMIDE;ADRENORPHIN;ADRENORPHIN (BOVINE);TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2;PROENKEPHALIN (206-213) (BOVINE) | | CAS: | 88377-68-8 | | MF: | C44H69N15O9S | | MW: | 984.18 | | EINECS: | | | Product Categories: | Peptide;CancerBiology | | Mol File: | 88377-68-8.mol |  |
| | ADRENORPHIN Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO | | form | Solid | | pka | 9.97±0.15(Predicted) | | color | White to off-white | | Sequence | H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2 |
| | ADRENORPHIN Usage And Synthesis |
| Uses | Adrenorphin is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with Ki of 12 nM. | | Biological Activity | adrenorphin (metorphamide) is a potent inhibitor of nicotine-induced adrenaline and noradrenaline release with ic50 value of 10 μm [1].adrenorphin (metorphamide) is an endogenous, c-terminally amidated, opioid octapeptide (tyr-gly-gly-phe-met-arg-arg-val-nh2) that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain [2].adrenorphin (metorphamide) is selective nicotine-induced adrenaline and noradrenaline release inhibitor and has higher than 100-fold more potent than the reported nicotine-induced adrenaline and noradrenaline release inhibitor met5-enkephalin. when tested with bovine adrenal chromaffin cells, adrenorphin (metorphamide) showed inhibition on 5 μm nicotine-induced atp release by almost 50% at 5μm and the inhibition was not in a dose-dependent manner [1]. in bioassays and binding assays, metorphamide exhibited high μ-binding activity, as well as κ-binding activity with nearly half percent toμ-binding activity, while showed no activity on δ-binding [2]. | | IC 50 | μ Opioid Receptor/MOR | | references | [1]. marley, p.d., k.i. mitchelhill, and b.g. livett, metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells. brain res, 1986. 363(1): p. 10-7.
[2]. weber, e., et al., metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. proc natl acad sci u s a, 1983. 80(23): p. 7362-6. |
| | ADRENORPHIN Preparation Products And Raw materials |
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