ADRENORPHIN

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Products Intro: Product Name:Tyr-Gly-Gly-Phe-Arg-Arg-Val-NH2
CAS:88377-68-8
Purity:>98% HPLC Package:5mg; 25mg; 100mg; 1g; 5g; 25g;100g Remarks:A0047
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Products Intro: Product Name:Adrenorphin
CAS:88377-68-8
Purity:98% Package:1KG;10KG;50KG
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Products Intro: Product Name:ADRENORPHIN
CAS:88377-68-8
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Products Intro: Product Name:Adrenorphin
CAS:88377-68-8
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Products Intro: Product Name:ADRENORPHIN
CAS: 88377-68-8
Purity:99% Package:1KG;7USD

ADRENORPHIN manufacturers

  • ADRENORPHIN
  • ADRENORPHIN pictures
  • $7.00 / 1KG
  • 2020-02-19
  • CAS: 88377-68-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100kg
ADRENORPHIN Basic information
Product Name:ADRENORPHIN
Synonyms:H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2;METORPHIN;METORPHINAMIDE;METORPHAMIDE;ADRENORPHIN;ADRENORPHIN (BOVINE);TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2;PROENKEPHALIN (206-213) (BOVINE)
CAS:88377-68-8
MF:C44H69N15O9S
MW:984.18
EINECS:
Product Categories:Peptide;CancerBiology
Mol File:88377-68-8.mol
ADRENORPHIN Structure
ADRENORPHIN Chemical Properties
density 1.42±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO
form Solid
pka9.97±0.15(Predicted)
color White to off-white
SequenceH-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
ADRENORPHIN Usage And Synthesis
Biological Activityadrenorphin (metorphamide) is a potent inhibitor of nicotine-induced adrenaline and noradrenaline release with ic50 value of 10 μm [1].adrenorphin (metorphamide) is an endogenous, c-terminally amidated, opioid octapeptide (tyr-gly-gly-phe-met-arg-arg-val-nh2) that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain [2].adrenorphin (metorphamide) is selective nicotine-induced adrenaline and noradrenaline release inhibitor and has higher than 100-fold more potent than the reported nicotine-induced adrenaline and noradrenaline release inhibitor met5-enkephalin. when tested with bovine adrenal chromaffin cells, adrenorphin (metorphamide) showed inhibition on 5 μm nicotine-induced atp release by almost 50% at 5μm and the inhibition was not in a dose-dependent manner [1]. in bioassays and binding assays, metorphamide exhibited high μ-binding activity, as well as κ-binding activity with nearly half percent toμ-binding activity, while showed no activity on δ-binding [2].
references[1]. marley, p.d., k.i. mitchelhill, and b.g. livett, metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells. brain res, 1986. 363(1): p. 10-7.
[2]. weber, e., et al., metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. proc natl acad sci u s a, 1983. 80(23): p. 7362-6.
ADRENORPHIN Preparation Products And Raw materials
Tag:ADRENORPHIN(88377-68-8) Related Product Information
(MET(O)5)-ENKEPHALIN [LEU5]-ENKEPHALIN MET-ENKEPHALIN-ARG-PHE H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-OH MERGL LEU-ENKEPHALIN-ARG MET-ENKEPHALIN-ARG-ARG H-TYR-LYS-GLY-ARG-CYCLO(-GLU-TYR-ILE-LYS)-LEU-ILE-THR-ARG-PRO-ARG-TYR-NH2 ADRENORPHIN (FREE ACID),ADRENORPHIN 1-5-adrenorphin(human ADRENORPHIN BAM 18P PEPTIDE E BAM-12P BAM-22P TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY ([125I]-TYR)-BAM-12P ([125I]-TYR)-BAM-22P

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