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| Product Name: | NQ301 | | Synonyms: | NQ301;NQ301 - Compound 211;NQ 301; NQ-301;2-((4-acetylphenyl)amino)-3-chloronaphthalene-1,4-dione;2-(4-Acetylanilino)-3-chloronaphthalene-1,4-dione;2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione;1,4-Naphthalenedione, 2-[(4-acetylphenyl)amino]-3-chloro-;NQ301 >=98% (HPLC) | | CAS: | 130089-98-4 | | MF: | C18H12ClNO3 | | MW: | 325.75 | | EINECS: | | | Product Categories: | | | Mol File: | 130089-98-4.mol |  |
| | NQ301 Chemical Properties |
| Melting point | 241-243 °C(Solv: ethanol (64-17-5)) | | Boiling point | 476.8±45.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO:10.0(Max Conc. mg/mL);30.7(Max Conc. mM) | | pka | -5.25±0.20(Predicted) | | form | powder | | color | faint red to dark red |
| | NQ301 Usage And Synthesis |
| Uses | NQ 301 possess antiplatelet effect, making it an antithrombotic agent. It significantly inhibited the collagen-?, thrombin-?, arachidonic acid-?, thapsigargin- and calcium ionophore A23187-?induced aggregation of washed human platelets. | | Biochem/physiol Actions | NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice. |
| | NQ301 Preparation Products And Raw materials |
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