NQ301
中文名称 | NQ301 |
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中文同义词 | 化合物NQ301;NQ301游离态;NQ 301,CD45抑制剂 |
英文名称 | NQ301 |
英文同义词 | NQ301;NQ301 - Compound 211;NQ 301; NQ-301;2-((4-acetylphenyl)amino)-3-chloronaphthalene-1,4-dione;2-(4-Acetylanilino)-3-chloronaphthalene-1,4-dione;2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione;1,4-Naphthalenedione, 2-[(4-acetylphenyl)amino]-3-chloro-;NQ301 >=98% (HPLC) |
CAS号 | 130089-98-4 |
分子式 | C18H12ClNO3 |
分子量 | 325.75 |
EINECS号 | |
相关类别 | |
Mol文件 | 130089-98-4.mol |
结构式 | ![]() |
NQ301 性质
熔点 | 241-243 °C(Solv: ethanol (64-17-5)) |
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沸点 | 476.8±45.0 °C(Predicted) |
密度 | 1.40±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:10.0(最大浓度 mg/mL);30.7(最大浓度 mM) |
酸度系数(pKa) | -5.25±0.20(Predicted) |
形态 | 粉末 |
颜色 | 淡红色至深红色 |
Target | Value |
TXA2 receptor
() | |
CD45
(Cell-free assay) | 200 nM |
NQ301 concentration-dependently inhibits collagen (10 mg/mL)-, U46619 (1 mg/mL)- and arachidonic acid (100 mg/mL)-challenged rabbit platelet aggregation, with IC 50 values of 0.60±0.02, 0.58±0.04 and 0.78±0.04 μM, respectively. NQ301 potently suppresses thromboxane B 2 formation by platelets that are exposed to arachidonic acid in a concentration-dependent manner, but had no effect on the production of prostaglandin D 2 , indicating an inhibitory effect on thromboxane A 2 synthase. NQ301 has a potential to inhibit thromboxane A 2 synthase activity with thromboxane A 2 /prostaglandin H 2 receptor blockade, and modulate arachidonic acid liberation as well as 12-hydroxy-5,8,10,14-eicosatetraenoic acid formation in platelets. NQ301 inhibits platelet aggregation by suppression of the intracellular pathway, rather than by direct inhibition of fibrinogen-GPIIb/IIIa complex binding. NQ301 significantly inhibits the increase of cytosolic Ca 2+ concentration and ATP secretion, and also significantly increases platelet cAMP levels in the activated platelets. The antiplatelet activity of NQ301 may be mediated by inhibition of cytosolic Ca 2+ mobilization, enhancement of cAMP production and inhibition of ATP secretion in activated platelets.
安全信息
危险品运输编号 | UN 3077 9 / PGIII |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101054 | NQ301 NQ301 | 130089-98-4 | 10mM * 1mLin DMSO | 660元 |
2024/04/30 | S0141 | NQ301 NQ301 | 130089-98-4 | 5mg | 668.78元 |