NQ301
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- CAS号:
- 130089-98-4
- 英文名:
- NQ301
- 英文别名:
- NQ301;NQ 301; NQ-301;NQ301 >=98% (HPLC);NQ301 - Compound 211;inhibit,Inhibitor,NQ-301,NQ301,NQ 301,Thrombin;2-(4-Acetylanilino)-3-chloronaphthalene-1,4-dione;2-((4-acetylphenyl)amino)-3-chloronaphthalene-1,4-dione;2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione;1,4-Naphthalenedione, 2-[(4-acetylphenyl)amino]-3-chloro-
- 中文名:
- NQ301
- 中文别名:
- NQ301游离态;化合物NQ301;NQ 301,CD45抑制剂;2-((4-乙酰基苯基)氨基)-3-氯萘-1,4-二酮
- CBNumber:
- CB81352274
- 分子式:
- C18H12ClNO3
- 分子量:
- 325.75
- MOL File:
- 130089-98-4.mol
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NQ301化学性质
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熔点:
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241-243 °C(Solv: ethanol (64-17-5))
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沸点:
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476.8±45.0 °C(Predicted)
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密度:
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1.40±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO:10.0(Max Conc. mg/mL);30.7(Max Conc. mM)
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酸度系数(pKa):
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-5.25±0.20(Predicted)
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形态:
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powder
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颜色:
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faint red to dark red
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NQ301性质、用途与生产工艺
NQ301 (Compound 211) 是一种抗血小板和抗血栓形成剂，也是一种选择性的 CD45 的抑制剂，IC50值为200 nM。NQ301 可抑制兔血小板中的 thromboxane A2 receptor (TXA2) 和合酶synthase的活性。
| Target | Value |
TXA2 receptor
()
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CD45
(Cell-free assay)
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200 nM
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NQ301 concentration-dependently inhibits collagen (10 mg/mL)-, U46619 (1 mg/mL)- and arachidonic acid (100 mg/mL)-challenged rabbit platelet aggregation, with IC
50
values of 0.60±0.02, 0.58±0.04 and 0.78±0.04 μM, respectively. NQ301 potently suppresses thromboxane B
2
formation by platelets that are exposed to arachidonic acid in a concentration-dependent manner, but had no effect on the production of prostaglandin D
2
, indicating an inhibitory effect on thromboxane A
2
synthase. NQ301 has a potential to inhibit thromboxane A
2
synthase activity with thromboxane A
2
/prostaglandin H
2
receptor blockade, and modulate arachidonic acid liberation as well as 12-hydroxy-5,8,10,14-eicosatetraenoic acid formation in platelets. NQ301 inhibits platelet aggregation by suppression of the intracellular pathway, rather than by direct inhibition of fibrinogen-GPIIb/IIIa complex binding. NQ301 significantly inhibits the increase of cytosolic Ca
2+
concentration and ATP secretion, and also significantly increases platelet cAMP levels in the activated platelets. The antiplatelet activity of NQ301 may be mediated by inhibition of cytosolic Ca
2+
mobilization, enhancement of cAMP production and inhibition of ATP secretion in activated platelets.
NQ301
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101054 | NQ301
NQ301 | 130089-98-4 | 5mg | 600元 |
| 2024/11/08 | HY-101054 | NQ301
NQ301 | 130089-98-4 | 10mM * 1mLin DMSO | 660元 |
130089-98-4, NQ301 相关搜索:
- 抑制剂
- 药靶配体
- 2-((4-乙酰基苯基)氨基)-3-氯萘-1,4-二酮
- NQ 301,CD45抑制剂
- NQ301游离态
- 化合物NQ301
- 130089-98-4
- inhibit,Inhibitor,NQ-301,NQ301,NQ 301,Thrombin
- NQ301 >=98% (HPLC)
- 1,4-Naphthalenedione, 2-[(4-acetylphenyl)amino]-3-chloro-
- 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
- 2-(4-Acetylanilino)-3-chloronaphthalene-1,4-dione
- 2-((4-acetylphenyl)amino)-3-chloronaphthalene-1,4-dione
- NQ 301; NQ-301
- NQ301 - Compound 211
- NQ301