|
|
| | 4,4,4-Trifluoro-3-oxobutanenitrile Basic information |
| Product Name: | 4,4,4-Trifluoro-3-oxobutanenitrile | | Synonyms: | 4,4,4-Trifluoro-3-oxobutanenitrile;4,4,4-Trifluoro-3-oxo-butyronitrile;Butanenitrile, 4,4,4-trifluoro-3-oxo-;Tofacitinib Impurity 232;Phloroglucinol Impurity 66 | | CAS: | 110234-68-9 | | MF: | C4H2F3NO | | MW: | 137.06 | | EINECS: | | | Product Categories: | | | Mol File: | 110234-68-9.mol |  |
| | 4,4,4-Trifluoro-3-oxobutanenitrile Chemical Properties |
| Boiling point | 43 °C(Press: 2.5 Torr) | | density | 1.350±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | pka | 2.74±0.10(Predicted) |
| | 4,4,4-Trifluoro-3-oxobutanenitrile Usage And Synthesis |
| Uses | 4,4,4-Trifluoro-3-oxobutanenitrile (cas# 110234-68-9) is used as a reagent in the preparation of ((dimethoxyquinazolinyloxy)phenyl)urea derivatives as orally efficacious inhibitors of V-RAF murine sarcoma viral oncogene. Additionally, it is used as a reagent in preparation of orally active inhibitors of Brahma homolog (BRM)/SMARCA2 ATPase activity for treatment of Brahma related gene 1 (BRG1)/SMARCA4-mutant cancers. It is also used as a reagent in the synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from fluorinated precursors. |
| | 4,4,4-Trifluoro-3-oxobutanenitrile Preparation Products And Raw materials |
|