| Company Name: |
Wuhan Sunrise Technology Development Co., Ltd.
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| Tel: |
027-027-83314682 13554138826 |
| Email: |
whsrtech@vip.163.com |
| Products Intro: |
Product Name:Obinutuzumab
CAS:949142-50-1
Purity:97% Package:2mg/vial, 20mg/vial , 100mg/vial
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| Company Name: |
Dalian Meilun Biotech Co., Ltd.
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| Tel: |
0411-62910999 13889544652 |
| Email: |
sales@meilune.com |
| Products Intro: |
Product Name:afutuzumab
CAS:949142-50-1
Purity:>95% Package:5MG
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| | Obinutuzumab Basic information |
| Product Name: | Obinutuzumab | | Synonyms: | Ga 101;Humab(cd20);Ro 5072759;Ro5072759;afutuzumab;Obinutuzumab/afutuzumab;Obinutuzumab;Research Grade Obinutuzumab(DHC90704) | | CAS: | 949142-50-1 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Obinutuzumab Structure]() |
| | Obinutuzumab Chemical Properties |
| | Obinutuzumab Usage And Synthesis |
| Description | In November 2013, the US FDA approved the glycoengineered, type II anti-CD20 antibody obinutuzumab (also known as GA101) in combination with chlorambucil chemotherapy for the treatment of people with previously untreated chronic lymphocytic leukemia (CLL). Obinutuzumab is the first drug approved under the FDA’s breakthrough therapy designation, created in 2012 to quicken the pace of development and review of drugs for serious conditions. The Fc portion of obinutuzumab was glycoengineered to reduce fucosylation of the Fc carbohydrate, resulting in increased FcγRIIIa affinity and antibody-dependent cellular cytotoxicity (ADCC) potency. As expected for a type II antibody, obinutuzumab demonstrated lower complement-mediated cytotoxicity, more potent mediation of cell death via the nonclassical apoptosis pathway and increased ADCC as compared with rituximab in preclinical studies. In addition, obinutuzumab induced a stronger antitumor effect in mouse xenograft models of human lymphoma than rituximab and ofatumumab, supporting clinical investigation of this third generation anti-CD20 antibody. | | Originator | GlycArt Biotechnology AG (United States) | | Brand name | Gazyva |
| | Obinutuzumab Preparation Products And Raw materials |
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