L-硒代蛋氨酸
中文名称 | L-硒代蛋氨酸 |
---|---|
中文同义词 | L(+)硒代蛋氨酸;L-硒代蛋氨;硒代蛋氨酸;L-(+)-硒代蛋氨酸;硒基-L-甲硫氨酸;(S)-(+)-2-氨基-4-(甲基硒)丁酸;-硒代蛋氨酸;L-SELENOMETHIONINE L-硒代蛋氨酸 |
英文名称 | L-Selenomethionine |
英文同义词 | (S)-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;(S)-2-AMINO-4-(METHYLSELENO)BUTYRIC ACID;SELENOMETHIONINE, L-(+)-;L-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;L-(+)-SELENOMETHIONINE;L-SELENOMETHIONINE;The L-selenoMethionine;L-SELENOMETHINONINE |
CAS号 | 3211-76-5 |
分子式 | C5H11NO2Se |
分子量 | 196.11 |
EINECS号 | 608-705-0 |
相关类别 | 医药原料药;化学试剂;氨基酸类;细胞信号和神经生物学;食品添加剂;氨基酸;新材料;对照品;功能性物质-硒代蛋氨酸;生化试剂-氨基酸类;化工;L-硒代蛋氨酸;化工原料;原料;医药原料;医用原料;食品添加;优势产品;Amino Acid Derivatives;Methionine [Met, M];Amino Acids;Antioxidant;Biochemistry;Biological-modified Amino Acids;Classes of Metal Compounds;Se (Selenium) Compounds;Semimetal Compounds;Seleno Amino Acid;amino acid;饲料添加剂;其他;高纯试剂;非天然氨基酸;化学产品;合成材料中间体 |
Mol文件 | 3211-76-5.mol |
结构式 | ![]() |
L-硒代蛋氨酸 性质
熔点 | 265 °C |
---|---|
比旋光度 | 18 º (c=1, 1N HCl) |
沸点 | 320.8±37.0 °C(Predicted) |
折射率 | 18 ° (C=0.5, 2mol/L HCl) |
储存条件 | -20°C |
溶解度 | H2O:50 mg/mL |
形态 | 粉末 |
酸度系数(pKa) | 2.26±0.10(Predicted) |
颜色 | 白色至类白色 |
水溶解性 | soluble |
Merck | 14,8441 |
InChI | InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 |
InChIKey | RJFAYQIBOAGBLC-BYPYZUCNSA-N |
SMILES | C(O)(=O)[C@@H](N)CC[Se]C |
LogP | 0.152 (est) |
CAS 数据库 | 3211-76-5(CAS DataBase Reference) |
Human Endogenous Metabolite
|
L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells.
L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells.
L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells.
L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation.
Cell Viability Assay
Cell Line: | Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) |
Concentration: | 1, 5, 10, 50, 100, 500 μM |
Incubation Time: | 24, 48, 72 hours |
Result: | Inhibited the growth of prostate cancer cells, with a lower IC 50 (1-90 μM) at 72 h than normal prostate cells (>500 μM). |
Apoptosis Analysis
Cell Line: | Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) |
Concentration: | 500 μM |
Incubation Time: | 48 hours |
Result: |
Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells.
Exhibited the nicked-end DNA labeling in prostate cancer cells. Promoted the PARP cleavage in prostate cancer cells. |
Cell Cycle Analysis
Cell Line: | Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) |
Concentration: | 500 μM |
Incubation Time: | 48 hours |
Result: |
Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%).
Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells. |
RT-PCR
Cell Line: | Human thyroid epithelial cells (HTori-3) |
Concentration: | 5 μM |
Incubation Time: | 24 hours |
Result: | Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells. |
L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles.
安全信息
危险品标志 | T,N |
---|---|
危险类别码 | 23/25-33-50/53 |
安全说明 | 20/21-28-45-60-61-28A |
危险品运输编号 | UN 3283 6.1/PG 2 |
WGK Germany | 3 |
RTECS号 | EK7713840 |
F | 10 |
危险等级 | 6.1 |
包装类别 | III |
海关编码 | 29309090 |
提供商 | 语言 |
---|---|
英文
|
|
英文
|
|
英文
|