- DIGITOXIGENIN
-
- $0.00 / 25kg
-
2024-04-12
- CAS:143-62-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000ton
|
| DIGITOXIGENIN Basic information |
Product Name: | DIGITOXIGENIN | Synonyms: | echujetin;evonogenin;3-beta,14-dihydroxy-5-beta,14-beta-card-20(22)-enolide;3β,14-dihydroxy-5β,20(22)-cardenolide;DIGITOXYGENIN;3β,14-Dihydroxy-5β,20(22)-cardenolide, 3,14,21-Trihydroxy-20(22)-norcholenic acid lactone, 5β,20(22)-Cardenolide-3β,14-diol, Digitoxigenin;3β,14-Dihydroxy-5β,20(22)-cardenolide, 3,14,21-Trihydroxy-20(22)-norcholenic acid lactone, 5β,20(22)-Cardenolide-3β,14-diol;THEVETIGENIN | CAS: | 143-62-4 | MF: | C23H34O4 | MW: | 374.51 | EINECS: | 205-603-4 | Product Categories: | Biochemistry;Steroids;Steroids (Others);ATPase | Mol File: | 143-62-4.mol | ![DIGITOXIGENIN Structure](CAS/GIF/143-62-4.gif) |
| DIGITOXIGENIN Chemical Properties |
Melting point | 253-255 °C (dec.)(lit.) | Boiling point | 423.5°C (rough estimate) | alpha | D17 +19.1° (c = 1.36 in methanol) | density | 1.0284 (rough estimate) | refractive index | 1.4433 (estimate) | storage temp. | Store at -20°C | solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml | form | powder to crystal | pka | 14.93±0.70(Predicted) | color | White to Almost white | Water Solubility | 11.24mg/L(30 ºC) | Merck | 14,3162 | BRN | 95448 | Stability: | Hygroscopic | LogP | 2.640 | CAS DataBase Reference | 143-62-4(CAS DataBase Reference) |
Hazard Codes | T | Risk Statements | 25 | Safety Statements | 45 | RIDADR | UN 3462 6.1/PG 2 | WGK Germany | 3 | RTECS | FH4975000 | HS Code | 2938.90.0000 | HazardClass | 6.1(a) | PackingGroup | II | Toxicity | cat,LDLo,intravenous,254ug/kg (0.254mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITING,Journal of the American Pharmaceutical Association. Vol. 27, Pg. 189, 1938. |
| DIGITOXIGENIN Usage And Synthesis |
Uses | Cardiotonic;Na+ K+ ATPase inhibitor | Definition | ChEBI: Digitoxigenin is a 5beta-cardenolide that is 5beta-cardanolide with hydroxy substituents at the 3beta- and 14beta-positions and double bond unsaturation at C(20)-C(22). It is a 3beta-hydroxy steroid and a 14beta-hydroxy steroid. It derives from a hydride of a 5beta-cardanolide. | Purification Methods | Dissolve digitoxigenin in EtOAc, wash it with H2O, dry it (Na2SO4), evaporate and recrystallise it from 40% aqueous EtOH or aqueous MeOH then EtOAc/Et2O. The UV has max at 218nm ( 14,500 M-1cm-1). The 3-acetate crystallises from Me2CO/Et2O with m 222-227o, [] D 20 +21o (c 1, CHCl3). [Wyss et al. Helv Chim Acta 43 644 1960, Cruz et al. J Org Chem 4 2 3580 1977, Beilstein 18 IV 1468.] |
| DIGITOXIGENIN Preparation Products And Raw materials |
|