- 5-INDANOL
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- $50.00 / 1KG
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2023-12-23
- CAS:1470-94-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 5-INDANOL
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- $0.00 / 25KG
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2022-09-03
- CAS:1470-94-6
- Min. Order: 25KG
- Purity: 97%
- Supply Ability: 1tons
- 5-Indanol
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- $9.80 / 1KG
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2020-02-11
- CAS:1470-94-6
- Min. Order: 1g
- Purity: >98%
- Supply Ability: 20 tons
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| 5-INDANOL Basic information | Uses |
| 5-INDANOL Chemical Properties |
Melting point | 51-53 °C (lit.) | Boiling point | 255 °C (lit.) | density | 0.8540 (rough estimate) | refractive index | 1.5630 (estimate) | Fp | >230 °F | storage temp. | Sealed in dry,Room Temperature | solubility | 6.3g/l | form | powder to crystal | pka | 10.37±0.20(Predicted) | color | slightly brown | BRN | 1936314 | CAS DataBase Reference | 1470-94-6(CAS DataBase Reference) | EPA Substance Registry System | 5-Indanol (1470-94-6) |
Hazard Codes | Xn,Xi | Risk Statements | 21-20/21/22 | Safety Statements | 36/37-36 | RIDADR | UN 2811 6.1/PG 3 | WGK Germany | 3 | RTECS | NK7525000 | Hazard Note | Irritant | HazardClass | 6.1 | PackingGroup | III | HS Code | 29062900 |
| 5-INDANOL Usage And Synthesis |
Uses | 5-Indanol is a 5-hydroxyindole analog with weak inhibitory activity against human melanoma tyrosinase. 5-Indanol is also used as a reagent in the preparation of Sodium Indanylcarbinicillin; a compound which has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic. | Description | 5-Indanol, mp 54–55 ℃, bp
255 ℃, is produced from indan [496-11-7] by
a sulfonation–alkali-fusion process. A
synthesis for 1,1,3,3-tetraalkylindanols was developed by Bayer, which involves
the reaction of isoolefins with secondary alkenylphenols (or compounds generating them
under the reaction conditions) at 100–250 ℃
and in the presence of acidic catalysts. An
example is the reaction of isobutene with bisphenol A in the presence of acid-activated
clays which yields 1,1,3,3-tetramethyl-5-indanol [53718-26-6], mp 115 ℃, bp (2.66 kPa)
156 ℃, in a yield of 80% of the theoretical,
and 4-tert-butylphenol as a coproduct. | Chemical Properties | light brown to grey-brown crystalline powder or | Uses | 5-Indanol is a 5-hydroxyindole analog with weak inhibitory activity against human melanoma tyrosinase. 5-Indanol is also used as a reagent in the preparation of Sodium Indanylcarbinicillin (S635000); a compound which has been shown to reduce blood pressure in mammals and also has been used as a b-lactam antibiotic. | Definition | ChEBI: A member of the class of phenols that is indan which has been hydroxylated at position 5. | Purification Methods | Crystallise 5-hydroxyindane from pet ether (m 56o) or pentane (m 59-60o). It has UV with max at 283.5nm (cyclohexane). The 3,5-dinitrobenzoyl derivative has m 156o. [Beilstein 6 III 2428, 6 IV 3829.] |
| 5-INDANOL Preparation Products And Raw materials |
Raw materials | Methanesulfonic acid, 1,1,1-trifluoro-, 2,3-dihydro-1H-inden-5-yl ester-->Indan-->4-INDANOL | Preparation Products | 2,3,3a,4,5,6,7,7a-octahydro-1H-inden-5-ol-->Acetic acid, 2-[(2,3-dihydro-1H-inden-5-yl)oxy]-, ethyl ester-->5-(2-bromoethoxy)-2,3-dihydro-1H-indene |
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