Company Name: |
Shanghai Tauto Biotech Co., Ltd.
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Tel: |
021-51320588 |
Email: |
tauto@tautobiotech.com |
Products Intro: |
Product Name:Sanguisorbigenin CAS:6812-98-2 Purity:98% Package:10mg;20mg;1gm;5gm;10gm;1KG
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| 3β-Hydroxyurs-12,19-dien-28-oic acid Basic information |
Product Name: | 3β-Hydroxyurs-12,19-dien-28-oic acid | Synonyms: | 3β-Hydroxyurs-12,19-dien-28-oic acid;Sanguisorbigenin;Tomentosolic acid;Ursa-12,19-dien-28-oic acid, 3-hydroxy-, (3β)-;19-Dehydroursolic acid;19-dien-28-oic acid;3β-Hydroxyurs-12;Ursa-12 | CAS: | 6812-98-2 | MF: | C30H46O3 | MW: | 454.7 | EINECS: | | Product Categories: | | Mol File: | 6812-98-2.mol | ![3β-Hydroxyurs-12,19-dien-28-oic acid Structure](CAS/20211123/GIF/6812-98-2.gif) |
| 3β-Hydroxyurs-12,19-dien-28-oic acid Chemical Properties |
Melting point | 267-268 °C (decomp) | Boiling point | 563.4±50.0 °C(Predicted) | density | 1.11±0.1 g/cm3(Predicted) | pka | 4.49±0.70(Predicted) | form | Solid | color | White to off-white |
| 3β-Hydroxyurs-12,19-dien-28-oic acid Usage And Synthesis |
Biological Activity | Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA)[1].
The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL[1]. The expression of blaR1, mecA and blaZ is significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression of mecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decrease PBP2a expression[1]. | References | [1]. S Wang, et al. Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol. 2021 Mar;72(3):238-244. |
| 3β-Hydroxyurs-12,19-dien-28-oic acid Preparation Products And Raw materials |
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