2,5-二羟基苯乙酮
中文名称 | 2,5-二羟基苯乙酮 |
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中文同义词 | 2',5'-二羟基苯乙酮;2,5-二羟基乙酰苯;2,5-二羥苯乙酮;2-乙醯氫醌;2,5-二羟基苯乙酮;2',5'-二羟基苯乙酮, 98+%;苯乙酮,2',5'-二羟基-;乙酮,1-(2,5-二羟苯基)- |
英文名称 | 2',5'-Dihydroxyacetophenone |
英文同义词 | 1-(2,5-dihydroxyphenyl)-ethanon;1-Acetyl-2,5-dihydroxybenzene;2,5-Dihydroxy-1-acetylbenzene;2’,5’-dihydroxy-acetophenon;Acetophenone, 2',5'-dihydroxy-;Acetylhydroquinone;QUINACETOPHENONE;2-Acetylhydroquinone Quinacetophenone |
CAS号 | 490-78-8 |
分子式 | C8H8O3 |
分子量 | 152.15 |
EINECS号 | 207-716-4 |
相关类别 | 苯乙酮;通用试剂;有机砌块;羰基化合物;酮;其它酚类;FINE Chemical & INTERMEDIATES;Aromatic Acetophenones & Derivatives (substituted);Building Blocks;C7 to C8;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks;合成材料中间体;对照品 |
Mol文件 | 490-78-8.mol |
结构式 | ![]() |
2,5-二羟基苯乙酮 性质
熔点 | 204-206 °C(lit.) |
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沸点 | 234.6°C (rough estimate) |
密度 | 1.2143 (rough estimate) |
折射率 | 1.4447 (estimate) |
储存条件 | Store below +30°C. |
溶解度 | 二恶烷:50 mg/mL,透明 |
形态 | 晶体或结晶粉末 |
酸度系数(pKa) | 9.86±0.18(Predicted) |
颜色 | 黄色至黄绿色 |
水溶解性 | insoluble |
BRN | 637903 |
InChIKey | WLDWSGZHNBANIO-UHFFFAOYSA-N |
LogP | 1.274 (est) |
CAS 数据库 | 490-78-8(CAS DataBase Reference) |
NIST化学物质信息 | Ethanone, 1-(2,5-dihydroxyphenyl)-(490-78-8) |
EPA化学物质信息 | Ethanone, 1-(2,5-dihydroxyphenyl)- (490-78-8) |
Target | Value |
iNOS
() | |
ERK1/2
() | |
NF-κB
() | |
TNF-α
() | |
IL-6
() |
2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells.
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