4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物
| 中文名称 | 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物 |
|---|---|
| 中文同义词 | 1,3-二[4-(7-氯-4-喹啉基)-1-哌嗪基]丙烷 四磷酸盐四水合物;四磷酸哌喹四水合物;4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物;磷酸哌喹四水物;化合物T7744;四磷酸哌喹 |
| 英文名称 | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate |
| 英文同义词 | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate;Piperaquine tetraphosphate tetrahydrate;1,3-Bis[4-(7-chloro-4-quinolinyl)-1-piperazinyl]propane tetraphosphate tetrahydrate;1,3-Bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane Tetraphosphate;artemisinin,Parasite,inhibit,antimalarial,drug-based,Inhibitor,Piperaquine tetraphosphate tetrahydrate,ACT,combination;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate;1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane tetrakis(phosphate) tetrahydrate |
| CAS号 | 915967-82-7 |
| 分子式 | C29H32Cl2N6.4(H3PO4).4(H2O) |
| 分子量 | 651.521041 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 915967-82-7.mol |
| 结构式 |  |
4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物 性质
| 熔点 | 252 °C(dec.) |
|---|---|
| 储存条件 | room temp |
| 溶解度 | H2O：≥10mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 敏感性 | Hygroscopic |
Piperaquine tetraphosphate tetrahydrate 是一种双喹啉抗疟药，可以与青蒿素联用于抗疟研究。
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.
Piperaquine (90 mg/kg; a single i.p.) exhibits the t
1/2
, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.
| Animal Model: | Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites |
| Dosage: | 0, 10, 30, 90 mg/kg |
| Administration: | A single i.p. administration |
| Result: |
The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg. |
| Animal Model: | Male Swiss mice (6 weeks old) |
| Dosage: | 90 mg/kg (Pharmacokinetic Analysis) |
| Administration: | A single i.p. administration |
| Result: | t 1/2 =17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-B1896B | 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物 Piperaquine tetraphosphate tetrahydrate | 915967-82-7 | 5mg | 200元 |
| 2024/08/19 | HY-B1896B | 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物 Piperaquine tetraphosphate tetrahydrate | 915967-82-7 | 10mg | 320元 |