- Tosyl isocyanate
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- $120.00 / 1kg
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2024-06-04
- CAS:4083-64-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20ton
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| | p-Toluenesulfonyl Isocyanate Basic information |
| | p-Toluenesulfonyl Isocyanate Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 14-36/37/38-42 | | Safety Statements | 26-28-30-28A | | RIDADR | UN 2206 6.1/PG 3 | | WGK Germany | 1 | | RTECS | DB9032000 | | F | 10 | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29309090 |
| | p-Toluenesulfonyl Isocyanate Usage And Synthesis |
| Chemical Properties | clear liquid | | Uses | It is a reagent used to prepare acetylated syn-1,2-diols,oxazolidin-2-ones, 2,3-diamino acids, and N-tosylcarbonamides. -Toluenesulfonyl isocyanate has been used as derivatization reagent in determination of 3-α-hydroxy tibolone in human plasma by LC-MS/MS. It is also employed in the derivatization reagent in simultaneous quantitative analysis of diethylene glycol and propylene glycol in pharmaceutical products by HPLC and as reagent in the preparation of acetylated syn-1,2-diols, oxazolidin-2-ones, 2,3-diamino acids and N-tosylcarbonamides. | | Uses | p-Toluenesulfonyl isocyanate is a reagent used to prepare acetylated syn-1,2-diols,1 oxazolidin-2-ones,2 2,3-diamino acids,3 and N-tosylcarbonamides.4 | | Synthesis Reference(s) | Tetrahedron Letters, 35, p. 9609, 1994 DOI: 10.1016/0040-4039(94)88523-0 | | General Description | p-Toluenesulfonyl isocyanate undergoes palladium-catalyzed bis-allylation reaction with allylstannanes and allyl chlorides. | | Reactivity Profile |
p‐Toluenesulfonyl Isocyanate (PTSI) is recommended especially for one‐component, low‐VOC polyurethane coatings. The reaction of PTSI with water introduced from pigments and solvents in the paint formulation generates carbon dioxide and soluble inert chemical products. Experience has demonstrated that 13 grams of PTSI effectively scavenges 1 gram of water. PTSI reacts with water in a 1 to 1 molar ratio, generating PTSA and carbon dioxide gas. This reaction occurs readily at room temperature and does not require heating. The PTSA generated in the process is essentially an inert material that does not further react with PTSI or other isocyanate groups, resulting in the formation of insoluble ureas. The hydroxyl group is reacted with excess p-toluenesulfonyl isocyanate (TSI) to form an acidic carbamate. Water is added to convert unreacted isocyanate to sulfonamide, followed by direct potentiometric titration of the acidic carbamate with tetrabutylammonium hydroxide (Bu4NOH) in nonaqueous medium.
| | Hazard | Moderately toxic by ingestion. Low toxicity by inhalation. A mild skin and moderate eye
irritant. | | Synthesis | Add the organic azide 4-methylbenzenesulfonyl azide (0.75 mmol), Pd(OAc)2 (5.6 mg, 5 mol%) to an oven-dried Schlenk tube (10 mL). Purge the tube and backfill with CO (three cycles) from a balloon. Inject anhydrous MeCN (3.0 mL) into the tube. Stir at 80 ℃ for 4 h under the CO atmosphere (balloon). Concentrate the mixture under reduced pressure. Purify the residue by column chromatography (petroleum ether/EtOAc 3:1.-.1:1) to afford p-Toluenesulfonyl Isocyanate.
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| | p-Toluenesulfonyl Isocyanate Preparation Products And Raw materials |
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