环巴胺抑制剂 1
中文名称 | 环巴胺抑制剂 1 |
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中文同义词 | 环巴胺抑制剂 1;6-(咪唑并[1,2-A]吡啶-3-基)-N-(哌啶-4-基)吡啶-2-胺;IRAK抑制剂1 |
英文名称 | 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine |
英文同义词 | 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine;Cyclopamine inhibitor 1;IRAK inhibitor 1;2-PyridinaMine, 6-iMidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-;2-a]pyridin-3-yl-N-4-piperidinyl-;6-imidazo[1;IRAK inhibitor;IRAK inhibitor 1,Inhibitor,inhibit,Interleukin-1 receptor associated kinase,IL-1R associated kinase,IRAK inhibitor1,IRAK inhibitor-1,IRAK |
CAS号 | 1042224-63-4 |
分子式 | C17H19N5 |
分子量 | 293.37 |
EINECS号 | |
相关类别 | |
Mol文件 | 1042224-63-4.mol |
结构式 |
环巴胺抑制剂 1 性质
密度 | 1.32 |
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储存条件 | Store at -20°C |
溶解度 | 不溶于乙醇;不溶于水; DMSO 中≥14.4 mg/mL |
形态 | 粉末 |
酸度系数(pKa) | 9.94±0.10(Predicted) |
颜色 | 浅黄至黄色 |
IC50: 216 nM (IRAK-4), 3.801 μM (JNK-1), >10 μM (JNK-2)
IRAK inhibitor 1 possesses significant potency in an IRAK-4 enzyme assay but is poorly active against JNK-1 and JNK-2. IRAK-4 is a novel member of the IRAK family with unique functional properties. IRAK-4 is the closest human homolog to Pelle. Endogenous IRAK-4 interacts with IRAK-1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK-4 can activate NF-κB as well as mitogen-activated protein (MAP) kinase pathways. Most strikingly, and in contrast to the other IRAKs, IRAK-4 depends on its kinase activity to activate NF-κB. In addition, IRAK-4 is able to phosphorylate IRAK-1, and overexpression of dominant-negative IRAK-4 is blocking the IL-1-induced activation and modification of IRAK-1, suggesting a role of IRAK-4 as a central element in the early signal transduction of Toll/IL-1 receptors, upstream of IRAK-1. IRAK-4 shares the domain structure of the other IRAKs and it is able to activate similar signal transduction pathways, namely NF-κB and MAPK pathways. It rapidly and transiently associates with IRAK-1 and TRAF6 in an IL-1-dependent manner but it is not functionally redundant with IRAK-1. IRAK-4 is an active protein kinase and requires its kinase activity to activate NF-κB. IRAK-4 might act upstream of IRAK-1 as an IRAK-1 activator.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-13275 | 环巴胺抑制剂 1 IRAK inhibitor 1 | 1042224-63-4 | 10mM * 1mLin DMSO | 1420元 |
2024/08/19 | HY-13275 | 环巴胺抑制剂 1 IRAK inhibitor 1 | 1042224-63-4 | 5mg | 2200元 |