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GAP 27

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Company Name: Shenzhen Nexconn Pharmatechs Ltd
Tel: +86-755-89396905 +86-15013857715
Email: admin@nexconn.com
Products Intro: Product Name:Gap 27
CAS:198284-64-9
Purity:98% Package:1KG;10KG;50KG
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Gap 27
CAS:198284-64-9
Purity:98% Package:10mg Remarks:BOC Sciences also provides custom synthesis services for Gap 27.
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name:GAP 27
CAS:198284-64-9
Purity:99% Package:1KG;7USD
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: CAS:198284-64-9
Purity:99% Package:5KG;1KG
Company Name: Alfa Chemistry
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Email: Info@alfa-chemistry.com
Products Intro: Product Name:Gap 27
CAS:198284-64-9
Remarks:https://www.alfa-chemistry.com/cas_198284-64-9.htm

GAP 27 manufacturers

  • GAP 27
  • GAP 27 pictures
  • $7.00 / 1KG
  • 2020-02-14
  • CAS:198284-64-9
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100KG
GAP 27 Basic information
Product Name:GAP 27
Synonyms:H-SER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE-OHSER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE;GAP 27;M.W. 1304.55 C60H101N15O17;Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile;L-Isoleucine, L-seryl-L-arginyl-L-prolyl-L-threonyl-L-α-glutamyl-L-lysyl-L-threonyl-L-isoleucyl-L-phenylalanyl-L-isoleucyl-;Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, >98%;GAP 27, >98%;GAP-27; GAP27
CAS:198284-64-9
MF:C60H101N15O17
MW:1304.53
EINECS:
Product Categories:Adhesion Molecules and Related Proteins;Cell Signaling and Neuroscience;Cytoskeleton and Extracellular Matrix;Various Peptides;Neuroscience
Mol File:198284-64-9.mol
GAP 27 Structure
GAP 27 Chemical Properties
density 1.40±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility Soluble at 1mg/ml in 1% acetic acid
pka3.41±0.10(Predicted)
form Solid
color White to off-white
Water Solubility Soluble to 1 mg/ml in water
SequenceH-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH
Safety Information
Safety Statements 22-24/25
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
GAP 27 Usage And Synthesis
UsesGap27 is a connexin (Cx) mimetic peptide that inhibits connexin-mediated communication (CMC). In vitro, Gap27 has been shown to improve cell migration during scrape-wound repair in hyperglycemia/hyperinsulinemia conditions. It also reduces acetylcholine-induced hyperpolarization in smooth muscle cells.
Biological Activitygap 27 is a peptide(ser-arg-pro-thr-glu-lys-thr-ile-phe-ile-ile) derived from connexin 43 that is a selective gap junction blocker.connexins, or gap junctions, are a family of structurally-related transmembrane proteins. gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells. this intercellular communication has been implicated in the coordination of cellular responses to intracellular signaling molecules. calcium and inositol phosphates are among the second messengers that can pass through gap junction channels. this synthetic connexin-mimetic peptide, gap 27, was used to evaluate the contribution of gap-junctional communication to osteoclastic bone resorption. it was concluded that gap-junctional communication is necessary for proper bone remodeling.figure1 formula of gap 27
storageStore at -20°C
references1. Berthoud, V. et al. Am. J. Physiol. Lung Cell Mol. Physiol. 279, 619 (2000)2. Ilvesaro, J. et al. BMC Musculoskel. Disord. 2, 10 (2001)3. Chaytor, A. et al. Brit. J. Pharmacol. 144, 108 (2005)4. Boitano, S. and H. Evans Am. J. Physio.l Lung Cell Mol. Physiol. 279, L623 ( 2000).
GAP 27 Preparation Products And Raw materials
Tag:GAP 27(198284-64-9) Related Product Information
H-ILE-ILE-OH GAP 27