- PPQ-102
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- $34.00 / 1mg
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2024-11-19
- CAS:931706-15-9
- Min. Order:
- Purity: ≥95%
- Supply Ability: 10g
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| | PPQ-102 Basic information |
| Product Name: | PPQ-102 | | Synonyms: | PPQ-102;7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE;PPQ-102, CFTR Inhibitor;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione;7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione PPQ-102;PPQ-102 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione;PPQ 102, >=98% | | CAS: | 931706-15-9 | | MF: | C26H22N4O3 | | MW: | 438.48 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 931706-15-9.mol |  |
| | PPQ-102 Chemical Properties |
| Melting point | >300℃ (ethanol ) | | Boiling point | 648.7±65.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | -20C | | solubility | DMF: 0.2 mg/ml | | form | White crystalline solid | | pka | 1.00±0.40(Predicted) | | color | Light yellow to yellow |
| | PPQ-102 Usage And Synthesis |
| Uses | PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1]. | | General Description | A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture. | | storage | Store at -20°C | | References | [1] Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55. DOI:10.1021/jm9009873 |
| | PPQ-102 Preparation Products And Raw materials |
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