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PPQ-102

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PPQ-102 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:PPQ-102
CAS:931706-15-9
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PPQ-102；CFTR Inhibitor;PPQ 102;PPQ102
CAS:931706-15-9
Purity:99.17% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:PPQ-102
CAS:931706-15-9
Purity:98% Package:5mg Remarks:V2875
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054
Email: trendseenbio@gmail.com
Products Intro: Product Name:PPQ-102
CAS:931706-15-9
Purity:99% Package:1kg；25kg
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:PPQ 102
CAS:931706-15-9
Purity:>=98%(HPLC) Package:$197.9/5mg;$346.9/10mg;$780.9/25mg;$1363.9/50mg;$2108.9/100mg;Bulk package Remarks:98%(HPLC)
PPQ-102 Basic information
Product Name:PPQ-102
Synonyms:PPQ-102;7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE;PPQ-102, CFTR Inhibitor;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione;7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione PPQ-102;PPQ-102 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione;PPQ 102, >=98%
CAS:931706-15-9
MF:C26H22N4O3
MW:438.48
EINECS:
Product Categories:Inhibitors
Mol File:931706-15-9.mol
PPQ-102 Structure
PPQ-102 Chemical Properties
Melting point >300℃ (ethanol )
Boiling point 648.7±65.0 °C(Predicted)
density 1.39±0.1 g/cm3(Predicted)
storage temp. -20C
solubility DMF: 0.2 mg/ml
form White crystalline solid
pka1.00±0.40(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
PPQ-102 Usage And Synthesis
General DescriptionA cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.
storageStore at -20°C
PPQ-102 Preparation Products And Raw materials
Tag:PPQ-102(931706-15-9) Related Product Information
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