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| | IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Basic information |
| Product Name: | IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea | | Synonyms: | IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea;PQ401;N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea;IGF-1R Inhibitor II;N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea;Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)-;1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea;N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)- | | CAS: | 196868-63-0 | | MF: | C18H16ClN3O2 | | MW: | 341.79 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 196868-63-0.mol |  |
| | IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Chemical Properties |
| density | 1.370±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: >10mg/mL | | form | White solid | | color | white |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 |
| | IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Usage And Synthesis |
| Uses | PQ 401, a novel diarylurea compound, is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R) autophosphorylation. Also used as a potential testing agent in the treatment of breast and other IGF-1-sensitive cancers. | | Definition | ChEBI: 1-(5-chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea is a member of quinolines. | | Biological Activity | Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC 50 value of 12 μ M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo . | | in vivo | a treatment with pq401 triple per week reduced the growth rate of mcneua cells implanted into mice [1]. | | storage | Store at +4°C | | references | [1]. gable kl, maddux ba, penaranda c, zavodovskaya m, campbell mj, lobo m, robinson l, schow s, kerner ja, goldfine id, youngren jf. diarylureas are small-molecule inhibitors of insulin-like growth factor i receptor signaling and breast cancer cell growth. mol cancer ther. 2006 apr;5(4):1079-86.
[2]. wang h, qin j, gong s, feng b, zhang y, tao j. insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt. endocrinology. 2014 jan;155(1):168-79. |
| | IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Preparation Products And Raw materials |
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