5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐
中文名称 | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐 |
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中文同义词 | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐;阿卡地新磷酸盐?, >98%;阿卡地新磷酸盐;化合物 T14149 |
英文名称 | AICAR (phosphate) |
英文同义词 | AICAR (phosphate);5-Amino-1-ribosylimidazole-4-carboxamide phosphate;AICAR (Acadesine) phosphate;AICAR phosphate, >98%;AICA Riboside phosphate);AICAR phosphate (Acadesine phosphate;Acadesine phosphate;ACADESINE PHOSPHATE;AICA RIBOSIDE PHOSPHATE |
CAS号 | 681006-28-0 |
分子式 | C9H17N4O9P |
分子量 | 356.23 |
EINECS号 | |
相关类别 | 对照品 |
Mol文件 | 681006-28-0.mol |
结构式 | ![]() |
5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐 性质
储存条件 | Store at -20°C |
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溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
颜色 | 白色至米白色 |
AMPK
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Autophagy
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Mitophagy
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HepG2 cells are treated with various concentrations of AICAR (0.1-1.0 mM) for 12, 24, and 48 h, respectively. The expression level of IR-β significantly decreases with 0.25, 0.5, and 1.0 mM of AICAR at 48 h to 50%, 53%, and 46% of the control, respectively.
Fourteen-week-old male, lean (L; 31.3 g body wt) wild-type andob/ob (O; 59.6 g body wt) mice are injected with the AMP-activated kinase (AMPK) activator AICAR (A) at 0.5 mg*g body wt -1 *day -1 or saline control (C) for 14 days. At 24 h after the last injection (including a 12-h fast), all mice are killed, and the plantar flexor complex muscle (gastrocnemius, soleus, and plantaris) is excised for analysis. Muscle mass is lower in OC (159±12 mg) than LC, LA, and OA (176±10, 178±9, and 166±16 mg, respectively) mice, independent of a body weight change. The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5 mg/g body wt) groups. The heart weight is higher in the exercise group than in the other groups, whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-13417A | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐 AICAR phosphate | 681006-28-0 | 50mg | 520元 |
2024/04/30 | HY-13417A | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐 AICAR phosphate | 681006-28-0 | 10mM * 1mLin Water | 572元 |