BETAMETHASONE HYDROCHLORIDE
| 中文名称 | BETAMETHASONE HYDROCHLORIDE |
|---|---|
| 中文同义词 | 盐酸倍他米松 |
| 英文名称 | BetaMethasone (hydrochloride) |
| 英文同义词 | BetaMethasone (hydrochloride) |
| CAS号 | 956901-32-9 |
| 分子式 | C28H38ClFO7 |
| 分子量 | 541.0485232 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 956901-32-9.mol |
| 结构式 |  |
BETAMETHASONE HYDROCHLORIDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 粉末 |
Betamethasone hydrochloride 是一种合成糖皮质激素，具有抗炎和免疫抑制活性。Betamethasone hydrochloride 可加速胎儿肺成熟并诱导基因表达和细胞凋亡。
Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells.
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis.
Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation.
Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain.
| Animal Model: | Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges |
| Dosage: | 0.48 mg |
| Administration: | Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h. |
| Result: |
Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.
The reduction in CBF was diminished to about 25-30 % after 48 h of infusion. |