- BLU 9931
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- $1.00 / 1KG
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2020-01-01
- CAS:1538604-68-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000KGS
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| | BLU9931 Basic information |
| Product Name: | BLU9931 | | Synonyms: | BLU 9931;BLU9931;BLU-9931;LM-3610;LM-3610; BLU9931;2-Propenamide,N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]-;BLU 9931;BLU-9931;BLU9931, 98%, a potent, selective, and irreversible FGFR4 inhibitor | | CAS: | 1538604-68-0 | | MF: | C26H22Cl2N4O3 | | MW: | 509.38 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1538604-68-0.mol |  |
| | BLU9931 Chemical Properties |
| density | 1.361±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥50.9 mg/mL in DMSO; insoluble in H2O; ≥2.53 mg/mL in EtOH with gentle warming and ultrasonic | | form | Powder | | pka | 13.15±0.70(Predicted) | | color | Off-white to light yellow |
| | BLU9931 Usage And Synthesis |
| Definition | BLU9931 is a potent, highly selective, and irreversible fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 3 nM and a Kd of 6 nM. BLU9931 has significant antitumor activity. BLU9931 makes a covalent bond with Cys552 within the ATP-binding pocket of FGFR4, which is not present in FGFR1-3. BLU9931 inhibited gastric cancer cell growth in a transplanted mouse model[1].
| | References | [1] Norihiko Sasaki. “FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.” Cancers (2020).
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| | BLU9931 Preparation Products And Raw materials |
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