环孢菌素 H
| 中文名称 | 环孢菌素 H |
|---|---|
| 中文同义词 | 环孢素H;环孢霉素H;环胞霉素B;环[L-丙氨酰-D-丙氨酰-N-甲基-L-亮氨酰-N-甲基-L-亮氨酰-N-甲基-L-缬氨酰-3-羟基-N,4-二甲基-L-2-氨基-6-辛烯酰-L-2-氨基丁酰-N-甲基甘氨酰-N-甲基-L-亮氨酰-L-缬氨酰-N-甲基-L-亮氨酰];环孢菌素 H;环孢菌素杂质H;环孢素H, 来源于小单孢菌;环孢素杂质8 |
| 英文名称 | Cyclosporin H |
| 英文同义词 | CYCLOSPORIN H;Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];5-(N-Methyl-D-valine)cyclosporin A;Cyclo[L-alanyl-D-alanyl-N-Methyl-L- leucyl-N-Methyl-L-leucyl-N-Methyl-D-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-diMethyl-L-2-aMinooctanoyl-L-2-aMinobutanoyl-N-Methylglycyl-N-Methyl-L-leucyl-L-valyl-N-Methyl-L-leucyl];Sandoz 37-839;Cyclosporin H, >=95%;Cyclosporine IMpurity-H;5-(N-Methyl-D-valine)cyclosporine A |
| CAS号 | 83602-39-5 |
| 分子式 | C62H111N11O12 |
| 分子量 | 1202.61 |
| EINECS号 | |
| 相关类别 | 对照品;免疫抑制剂;原料药;抑制剂;微生物代谢物;分析试剂-对照品;医用原料;ACTIVE PHARMACEUTICAL INGREDIENTS;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;原料;环孢素;医药原料;原料药及中间体;杂质对照品 |
| Mol文件 | 83602-39-5.mol |
| 结构式 |  |
环孢菌素 H 性质
| 熔点 | 148-151°C |
|---|---|
| 沸点 | 1293.8±65.0 °C(Predicted) |
| 密度 | 1.016±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 氯仿（微溶）、甲醇（微溶、加热、超声处理） |
| 酸度系数(pKa) | 13.32±0.70(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 旋光性 (optical activity) | [α]/D -100 to -115°, c = 0.5 in methanol |
The cyclic undecapeptide, cyclosporin H, is a potent inhibitor of formyl-Met-Leu-Phe (FMLP)-induced superoxide anion (O2-) formation in human neutrophils. Cyclosporin H inhibits FMLP binding in HL-60 membranes with a K i of 0.1 μM. Cyclosporin H inhibits activation by FMLP of high affinity GTPase (the enzymatic activity of alpha-subunits of heterotrimeric regulatory guanine nucleotide-binding proteins) in HL-60 membranes with a K i of 0.79 μM. Cyclosporin H inhibits the stimulatory effects of FMLP on cytosolic Ca 2+ concentration ([Ca 2+ ]i), O2- formation, and beta-glucuronidase release with K i values of 0.08, 0.24, and 0.45 μM, respectively.
Cyclosporin H (5 mg/kg; i.p.; before LPS or HCl challenge) attenuats lung injury induced by LPS or HCl (a lung injurymodel).
安全信息
| 海关编码 | 29420000 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-P1122 | Cyclosporin H | 1 mg | 1236元 | |
| 2024/11/08 | HY-P1122 | 环孢菌素 H Cyclosporin H | 83602-39-5 | 5mg | 3400元 |