- Sacubitrilat
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- $41.00 / 1mg
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2024-11-19
- CAS:149709-44-4
- Min. Order:
- Purity: 99.17%
- Supply Ability: 10g
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| | Sacubitril Impurity 7 Basic information |
| Product Name: | Sacubitril Impurity 7 | | Synonyms: | LBQ657;Sacubitrilat;(2R,4S)-4-(3-carboxypropanoylamino)-2-methyl-5-(4-phenylphenyl)pentanoic acid;LCZ696-4;Diacid of Sacubitril;LCZ-696 Impurity 1;Sacubitrilat (LBQ-657);Sacubitril Desethyl Impurity | | CAS: | 149709-44-4 | | MF: | C22H25NO5 | | MW: | 383.44 | | EINECS: | | | Product Categories: | | | Mol File: | 149709-44-4.mol |  |
| | Sacubitril Impurity 7 Chemical Properties |
| Boiling point | 705.4±60.0 °C(Predicted) | | density | 1?+-.0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMF:30.0(Max Conc. mg/mL);78.24(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.3(Max Conc. mM) | | form | A crystalline solid | | pka | 4.59±0.23(Predicted) | | color | White to off-white | | optical activity | [α]/D -35 to -27°, c =1 in methanol |
| | Sacubitril Impurity 7 Usage And Synthesis |
| Uses | Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure. | | Biological Activity | LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysinμs degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. |
| | Sacubitril Impurity 7 Preparation Products And Raw materials |
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