6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile manufacturers
|
| 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Basic information |
Product Name: | 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile | Synonyms: | 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile;6-Bromo-4-methoxypyrazoL;o[1,5-a]pyridine-3-carbonitriL;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-methoxy-;LOXO-292 intermediate;6-bromo-4-methoxypyrazole[1,5-a]pyridine-3-carbonitrile;6-bromo-4-methoxypyrazolol[.5-alpyridine-3-carbonitrile;6-Bromo-4-methoxypyrazolo [1,5-A] pyridine-3-acetonitrile | CAS: | 1207836-10-9 | MF: | C9H6BrN3O | MW: | 252.07 | EINECS: | 210-745-2 | Product Categories: | 1207836-10-9 | Mol File: | 1207836-10-9.mol | |
| 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Chemical Properties |
density | 1.67±0.1 g/cm3(Predicted) | storage temp. | Sealed in dry,Room Temperature | pka | -1.97±0.30(Predicted) | form | Solid | InChI | InChI=1S/C9H6BrN3O/c1-14-8-2-7(10)5-13-9(8)6(3-11)4-12-13/h2,4-5H,1H3 | InChIKey | JTEWRYBKHXGXHP-UHFFFAOYSA-N | SMILES | C12=C(C#N)C=NN1C=C(Br)C=C2OC |
| 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Usage And Synthesis |
Description | 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a pharmaceutical intermediate ingredient for the preparation of Selpercatinib, indicated for the treatment of patients with advanced cancers who test positive for certain RETs. | Uses | 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is an organic intermediate for laboratory R&D processes. | Synthesis | The DMF 10L solution of 2,4,6-trimethylbenzenesulfonic acid 3-bromo-5-methoxypyridinamine salt 2000g (4.96mol, 1.0eq), 2-chloropropene cyanide (7.44mol, 1.5eq) was added with potassium carbonate 684g (4.96mol, 1.0eq) and stirred at 20-30°C for 8h. Then the mixtrue was heated with dropwise 1132g (7.44mol, 1.5eq) of diazabicyclo at 50-60°C for 20h. After the reaction is finished and poured into water 30 L at RT. the solution was filtered, washed with water and recrystallized in ethanol to give a pale yellow solid, 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (702g 56%). |
| 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Preparation Products And Raw materials |
|