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| | GTP-GAMMA-S TETRALITHIUM SALT Basic information |
| Product Name: | GTP-GAMMA-S TETRALITHIUM SALT | | Synonyms: | GTP-GAMMA-S TETRALITHIUM SALT;GTP-GAMMA-S 4LI;GTP-GAMMA-S-LI4;Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetralithium salt;GTPγS tetralithium salt;GUANOSINE 5'-(TRIHYDROGEN DIPHOSPHATE), MONOANHYDRIDE WITH PHOSPHOROTHIOIC ACID, TETRALITHIUM;GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE TETRALITHIUM SALT;GUANOSINE-5'-O-(3-THIOTRIPHOSPHATE) TETRALITHIUM | | CAS: | 94825-44-2 | | MF: | C10H17LiN5O13P3S | | MW: | 547.19 | | EINECS: | 305-606-1 | | Product Categories: | | | Mol File: | 94825-44-2.mol |  |
| | GTP-GAMMA-S TETRALITHIUM SALT Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: ≥75 mg/mL Solutions are very unstable; prepare immediately prior to use. | | form | powder | | color | off-white | | Water Solubility | Water: 75 mg/ml | | BRN | 8182249 |
| | GTP-GAMMA-S TETRALITHIUM SALT Usage And Synthesis |
| Uses | Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:
- as a component of lysis buffer
- in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state
- to couple with G- protein α, to study its effect on kinase activity
| | General Description | G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells. | | Biochem/physiol Actions | GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro. |
| | GTP-GAMMA-S TETRALITHIUM SALT Preparation Products And Raw materials |
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