OSW-1
| 中文名称 | OSW-1 |
|---|---|
| 中文同义词 | 化合物 T21251;(3BETA,16BETA)-16-[[2-O-乙酰基-3-O-[2-O-(4-甲氧基苯甲酰基)-BETA-D-吡喃木糖基]-ALPHA-L-吡喃阿拉伯糖基]氧基]-3,17-二羟基胆甾-5-烯-22-酮 |
| 英文名称 | OSW-1 |
| 英文同义词 | OSW-1;16beta-[2-O-Acetyl-3-O-[2-O-(4-Methoxybenzoyl)-beta-D-xylopyranosyl)-alpha-L-arabinopyranosyloxy]-3b;Cholest-5-en-22-one, 16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3β,16β)-;OSW-1, >90% (Orsaponin);Cholest-5-en-22-one,16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-b-D-xylopyranosyl]-a-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3b,16b)-;Orsaponin;OSW-1 (Orsaponin);(3β,16β)-16-[[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxycholest-5-en-22-one |
| CAS号 | 145075-81-6 |
| 分子式 | C47H68O15 |
| 分子量 | 873.03 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 145075-81-6.mol |
| 结构式 |  |
OSW-1 性质
| 沸点 | 932.5±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.31±0.1 g/cm3(Predicted) |
| 储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 溶解度 | 可溶于氯仿（微量）、甲醇（微量）、吡啶（微量） |
| 酸度系数(pKa) | 12.65±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
OSBP/ORP4.
OSW-1 has a strong inhibitory effect on colon carcinoma cells with low cytotoxicity on normal cells. The anti-proliferative effects of OSW-1 on SW480 and LoVo colon carcinoma cells are characterized by measuring cell viability using the CCK8 assay, and compared the results with other clinical anticancer agents. SW480 and LoVo cell lines are derived from a Dukes' stage B colon carcinoma and a colon carcinoma metastatic nodule, which represent non-metastatic and metastatic carcinomas, respectively. OSW-1 exhibits not only extremely strong anticancer activity in SW480 and LoVo cell lines with an IC 50 of nanomolar concentration, but is also more potent than other anticancer agents by 10-100 times, with a lower cytotoxic effect on normal epithelial cells. These results indicate that OSW-1 has a powerful anticancer effect, but lower cytotoxic effect on normal cells.
To ascertain whether or not OSW-1 is as effective in vivo, a nude mouse model inoculated by LoVo cells is adopted, in which OSW-1 treatment is performed when tumors became palpable. The results show that the size of tumors in treated mice is smaller on average than control mice. The significant difference is observed from the 15-17 th day following treatment, and this difference is gradually increased until the animals are sacrificed. Compared with the control group, the tumor weight of the OSW-1-treated group significantly decreases (P<0.05). Additionally, no apparent side effects are observed in OSW-1-treated mice. These results demonstrate that OSW-1 has powerful effects on suppressing colon tumor growth without significant side effects in vivo.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101213 | OSW-1 OSW-1 | 145075-81-6 | 1mg | 3800元 |
| 2024/01/25 | HY-101213 | OSW-1 OSW-1 | 145075-81-6 | 5mg | 7800元 |