OSW-1 manufacturers
- OSW-1
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- $8.00 / 1KG
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2021-01-06
- CAS:145075-81-6
- Min. Order: 1g
- Purity: Min98% HPLC/GC
- Supply Ability: g/kg/ton
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| Product Name: | OSW-1 | | Synonyms: | OSW-1;16beta-[2-O-Acetyl-3-O-[2-O-(4-Methoxybenzoyl)-beta-D-xylopyranosyl)-alpha-L-arabinopyranosyloxy]-3b;Cholest-5-en-22-one, 16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3β,16β)-;OSW-1, >90%
(Orsaponin);Cholest-5-en-22-one,16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-b-D-xylopyranosyl]-a-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3b,16b)-;Orsaponin;OSW-1 (Orsaponin);(3β,16β)-16-[[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxycholest-5-en-22-one | | CAS: | 145075-81-6 | | MF: | C47H68O15 | | MW: | 873.03 | | EINECS: | | | Product Categories: | | | Mol File: | 145075-81-6.mol |  |
| | OSW-1 Chemical Properties |
| Boiling point | 932.5±65.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) | | pka | 12.65±0.70(Predicted) | | form | Solid | | color | White to Off-White |
| | OSW-1 Usage And Synthesis |
| Description | OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities. It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with Ki values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates. It induces OSBP translocalization from the cytoplasm to the trans-Golgi network and decreases intracellular levels of OSBP in HEK293 cells. OSW-1 inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM), including replication of coxsackievirus B3 (CVB3) in infected HeLa R19 cells in an OSBP-dependent manner when used at a concentration of 3 nM. It also inhibits replication of hepatitis C virus (HCV) but not mouse hepatitis virus (MHV), a coronavirus. It protects against CVA9 and echovirus 2 infection in HeLa cells when used at a concentration of 10 nM. OSW-1 inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively). | | Uses | OSW-1 is a unique steroidal saponin displaying selective cytotoxicity against cancer cell lines. From Ornithogalum Saundersiae bulbs. |
| | OSW-1 Preparation Products And Raw materials |
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