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| | CHAETOGLOBOSIN A Basic information |
| Product Name: | CHAETOGLOBOSIN A | | Synonyms: | CHAETOGLOBOSINB;CHAETOGLOBOSINM;CHAETOGLOBOSINE;CHAETOGLOBOSINL;(13)cytochalasa-13,17,21-triene-1,20,23-trione,6,7-epoxy-19-hydroxy-10-(1h-ind;18-dimethyl-,(7s,13e,16s,17e,19r,21e)-ol-3-yl)-1;chaetoglobosins;CHAETOGLOBOSIN | | CAS: | 50335-03-0 | | MF: | C32H36N2O5 | | MW: | 528.64 | | EINECS: | | | Product Categories: | Antibiotic | | Mol File: | 50335-03-0.mol |  |
| | CHAETOGLOBOSIN A Chemical Properties |
| Melting point | 188°C | | Boiling point | 608.81°C (rough estimate) | | density | 1.1705 (rough estimate) | | refractive index | 1.5800 (estimate) | | storage temp. | -20°C | | solubility | DMSO: soluble10mg/mL | | form | solid | | pka | 17.32±0.30(Predicted) | | color | Yellow | | Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| WGK Germany | 3 | | HS Code | 2941900000 |
| | CHAETOGLOBOSIN A Usage And Synthesis |
| Description | Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3 | | Occurrence | A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth
in wheat coleoptiles. | | Uses | Chaetoglobosin A is a mycotoxic cytochalasan compound. | | Definition | ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii. | | storage | +4°C | | References | 1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734
2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289
3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262 |
| | CHAETOGLOBOSIN A Preparation Products And Raw materials |
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