TYR-GLY-GLY-PHE-LEU-NH2
中文名称 | TYR-GLY-GLY-PHE-LEU-NH2 |
---|---|
中文同义词 | 2-[[2-[[2-[[2-[[2-AMINO-3-(4-HYDROXYPHENYL)PROPANOYL]AMINO]ACETYL]AMINO]ACETYL]AMINO]-3-PHENYLPROPANOYL]AMINO]-4-METHYLPENTANAMIDE;受体激动剂多肽LEU-ENKEPHALIN, AMIDE |
英文名称 | LEU-ENKEPHALIN AMIDE |
英文同义词 | ALPHA-NEOENDORPHIN (1-5) AMIDE;leucine enkephalinamide acetate;DYNORPHIN A (1-5) AMIDE;DYNORPHIN A (1-5) AMIDE ACETATE SALT;H-TYR-GLY-GLY-PHE-LEU-NH2;H-TYR-GLY-GLY-PHE-LEU-NH2 ACETATE SALT;LEU-ENKEPHALIN NH2;LEU-ENKEPHALIN AMIDE |
CAS号 | 60117-24-0 |
分子式 | C28H38N6O6 |
分子量 | 554.64 |
EINECS号 | |
相关类别 | |
Mol文件 | 60117-24-0.mol |
结构式 |
TYR-GLY-GLY-PHE-LEU-NH2 性质
熔点 | 123-126 °C |
---|---|
沸点 | 1012.8±65.0 °C(Predicted) |
密度 | 1.254±0.06 g/cm3(Predicted) |
储存条件 | −20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
酸度系数(pKa) | 9.97±0.15(Predicted) |
颜色 | 白色至米白色 |
δ opioid receptor
[Leu5]-Enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC 50 value of 2.1 nM.
Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05).
安全信息
WGK Germany | 3 |
---|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-P1470 | [Leu5]-Enkephalin, amide | 5 mg | 481元 | |
2024/04/30 | HY-P1470 | TYR-GLY-GLY-PHE-LEU-NH2 [Leu5]-Enkephalin, amide | 60117-24-0 | 10mg | 770元 |