- KETANSERIN TARTRATE
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- $66.00 / 1kg
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2024-10-17
- CAS:83846-83-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 300tons
- Ketanserin tartrate
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- $0.00 / 1Kg/Bag
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2024-10-14
- CAS:83846-83-7
- Min. Order: 10g
- Purity: 99%min
- Supply Ability: 10kg
- KETANSERIN TARTRATE
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- $50.00 / 1kg
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2023-06-19
- CAS:83846-83-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000tons
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| KETANSERIN TARTRATE Basic information |
Product Name: | KETANSERIN TARTRATE | Synonyms: | R 41468;R 41468 TARTRATE SALT;3-(2-(4-(p-fluorobenzoyl)-1-piperidinyl)ethyl)-2,4(1h,3h)-quinazolinedionel;4(1h,3h)-quinazolinedione,3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-(;kjk-945;r-(r*,r*))-2,3-dihydroxybutanedioate(1:1);3-[2-[4-(4-fluorobenzoyl)piperidino]ethyl]quinazoline-2,4(1H,3H)-dione [R-(R*,R*)]-tartrate;KETANSERIN TARTRATE (R 41468) (SELECTIVE 5-HT2/5-HT1C SEROTONI | CAS: | 83846-83-7 | MF: | C26H28FN3O9 | MW: | 545.52 | EINECS: | 281-062-8 | Product Categories: | Serotonin;Cardiovascular APIs;Serotonin receptor | Mol File: | 83846-83-7.mol | |
| KETANSERIN TARTRATE Chemical Properties |
Melting point | 183~186℃ | storage temp. | 2-8°C | solubility | ethanol: 3.3mg/mL | form | solid | color | white | Water Solubility | Soluble to 10 mM in water | CAS DataBase Reference | 83846-83-7(CAS DataBase Reference) |
Hazard Codes | T | Risk Statements | 25 | Safety Statements | 22-36/37/39-45 | RIDADR | UN 2811 6.1/PG 3 | WGK Germany | 3 | RTECS | VA1411195 | HazardClass | 6.1 | HS Code | 29335990 | Toxicity | LD50 oral in rat: 129mg/kg |
| KETANSERIN TARTRATE Usage And Synthesis |
Description | Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). It has no activity at 5-HT1 receptors but does have activity at histamine type 1, α1-adrenergic, and dopamine receptors with Ki values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia. | Uses | Selective 5-HT2A serotonin receptor antagonist | Uses | coccidiostat | Biological Activity | Selective 5-HT 2A serotonin receptor antagonist; can also be used to discriminate between 5-HT 1D and 5-HT 1B receptor subtypes. | Biochem/physiol Actions | Selective 5-HT2 serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction. | storage | Room temperature |
| KETANSERIN TARTRATE Preparation Products And Raw materials |
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