化合物 T14568
中文名称 | 化合物 T14568 |
---|---|
中文同义词 | 化合物 T14568;化合物 BI8622 |
英文名称 | BI8622 |
英文同义词 | BI8622;BI8622 (BI-8622;4-Pyrimidinecarboxamide, N-[4-(aminomethyl)phenyl]-6-(4-cyano-4-phenyl-1-piperidinyl)-5-methyl- |
CAS号 | 1875036-74-0 |
分子式 | C25H26N6O |
分子量 | 426.51 |
EINECS号 | |
相关类别 | |
Mol文件 | 1875036-74-0.mol |
结构式 |
化合物 T14568 性质
沸点 | 632.6±55.0 °C(Predicted) |
---|---|
密度 | 1.29±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:125 mg/mL(293.08 mM;需要超声波) |
形态 | 固体 |
酸度系数(pKa) | 11.59±0.70(Predicted) |
颜色 | 白色至米白色 |
IC50: 3.1 μM (HUWE1)
BI8622 induces HUWE1 ectopically expresses to abolish ubiquitination of MCL1 with an IC
50
value of 6.8 μM in HeLa cells.
BI8622 suppresses colony formation of Ls174T cells with estimated IC
50
value of 8.4 μM.
BI8622 (10 μM; 1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1.
BI8622 (0-50 μM; 16 hours) retards the degradation of MCL1 in response to UV irradiation by inhibiting HUWE1 in HeLa cells.
BI8622 inhibits MYC-dependent transactivation in colorectal cancer cells.
Cell Cycle Analysis
Cell Line: | Ls174T cells |
Concentration: | 0 μM, 5 μM,10 μM, 15 μM, 20 μM |
Incubation Time: | 0-4 days |
Result: | Retarded passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1. |
Western Blot Analysis
Cell Line: | HeLa cells |
Concentration: | 0 μM, 10 μM, 20 μM |
Incubation Time: | 16 hours |
Result: | Retarded the degradation of MCL1 in response to UV irradiation by inhibiting HUWE1 in HeLa cells. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-120929 | BI8622 | 1 mg | 1300元 | |
2024/08/19 | HY-120929 | 化合物 T14568 BI8622 | 1875036-74-0 | 5mg | 2900元 |