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4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

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4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Thalidomide-PEG2-C2-NH2；Thalidomide-NH-PEG2-C2-NH2
CAS:2093416-32-9
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
Tel: +86-0533-2185556 +8617865335152
Email: Mandy@hangyubiotech.com
Products Intro: CAS:2093416-32-9
Purity:0.99 Package:5KG;1KG
Company Name: Suzhou Highfine Biotech Co., Ltd  
Tel: 0512-69209928 18306219933
Email: paul@highfine.com
Products Intro: Product Name:4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2093416-32-9
Purity:98% Package:50g;100g; 500g;1kg;5kg;25kg
Company Name: Daicel Chiral Technologies (China)CO.,LTD  
Tel: 021-50460086-9 15921403865
Email: han_yajun@dctc.daicel.com
Products Intro: Product Name:4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2093416-32-9
Purity:95% Package:250mg;1g Remarks:209644
Company Name: ChemShuttle, Inc.  
Tel: 0510-83588313-802 18800520310;
Email: sales@chemshuttle.com
Products Intro: Product Name:4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2093416-32-9
Purity:95% Package:5mg;25mg;100mg;500mg;1g;5g;10g;25g;50g;100g;250g;500g;kg…
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Basic information
Product Name:4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Synonyms:4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;Thalidomide-NH-PEG2-C2-NH2;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;Thalidomide-PEG2-C2-NH2;Thalidomide-4-NH-PEG2-C2-NH2
CAS:2093416-32-9
MF:C19H24N4O6
MW:404.42
EINECS:
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Mol File:2093416-32-9.mol
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Structure
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties
Safety Information
MSDS Information
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Usage And Synthesis
Biological ActivityThalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials
Tag:4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione(2093416-32-9) Related Product Information
Thalidomide-O-amido-C2-NH2 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione -alkylC5-amine Thalidomide-NH-C6-NH2 TFA 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl E3 ligase Ligand-Linker Conjugates 15 Thalidomide-O-amido-C2-NH2 Thalidomide-NH-PEG2-C2-NH2 hydrochloride Thalidomide-NH-PEG2-C2-NH2 (TFA)