| Company Name: |
Amadis Chemical Company Limited |
| Tel: |
571-89925085 |
| Email: |
sales@amadischem.com |
| Products Intro: |
Product Name:1,2,4-Triazolo[4,3-b]pyridazine,3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-
CAS:286456-42-6
Purity:0.97 Package:mgs,gs,kgs Remarks:A876667
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| | L-838417 Basic information |
| Product Name: | L-838417 | | Synonyms: | 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-β]pyridazine;7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine;1,2,4-Triazolo[4,3-b]pyridazine,3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-;L-838417 ;3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine;5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole;L-838417_x000b_ | | CAS: | 286456-42-6 | | MF: | C19H19F2N7O | | MW: | 399.4 | | EINECS: | | | Product Categories: | Heterocycles;Intermediates & Fine Chemicals;Heterocyclic Compounds;Pharmaceuticals | | Mol File: | 286456-42-6.mol |  |
| | L-838417 Chemical Properties |
| Melting point | 196-198°C | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMSO: ≥20mg/mL | | pka | 2.13±0.10(Predicted) | | form | powder | | color | white to off-white |
| | L-838417 Usage And Synthesis |
| Chemical Properties | White to Off-White Solid | | Uses | L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties. | | Uses | A selective ligand for GABAA receptors | | Biological Activity | Subtype-selective GABA A receptor partial agonist. Selectively binds to α 1, α 2, α 3 and α 5 subunits (K i values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α 1 ( α 1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo . | | storage | Store at +4°C |
| | L-838417 Preparation Products And Raw materials |
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