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| | EURYCOMALACTONE(P) Basic information |
| Product Name: | EURYCOMALACTONE(P) | | Synonyms: | EURYCOMALACTONE(P);(1R,12R)-1,5,5a,7,7aα,11,11aβ,11b-Octahydro-1β,11β-dihydroxy-5aβ,8,11bα,12-tetramethyl-2β,5β-methanonaphth[1,2-d]oxepine-4,6,10(2H)-trione;Eurycomalatone;EURYCOMALACTONE(SH);EURYCOMALACTONE(AS);Eurycomalactone;2,5-Methanonaphth[1,2-d]oxepin-4,6,10(2H)-trione, 1,5,5a,7,7a,11,11a,11b-octahydro-1,11-dihydroxy-5a,8,11a,12-tetramethyl-, (1R,2R,5S,5aR,7aS,11S,11aS,11bR,12R)-;DNA double-strand,Eurycomalactone,NF-κB,protein synthesis,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,cisplatin,cyclin D1,inhibit,Eurycoma longifolia Jack | | CAS: | 23062-24-0 | | MF: | C19H24O6 | | MW: | 348.39 | | EINECS: | | | Product Categories: | | | Mol File: | 23062-24-0.mol |  |
| | EURYCOMALACTONE(P) Chemical Properties |
| Melting point | 267～270℃ | | Boiling point | 588.1±50.0 °C(Predicted) | | density | 1.328±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | Soluble in DMSO | | form | Solid | | pka | 12.22±0.70(Predicted) | | color | White to off-white |
| | EURYCOMALACTONE(P) Usage And Synthesis |
| Uses | Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394)[1][2][3]. | | Definition | ChEBI: Eurycomalactone is a steroid lactone. | | References | [1] Dukaew N, et, al. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G?/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair. Oncol Res. 2020 Mar 27;28(2):161-175. DOI:10.3727/096504019X15736439848765
[2] Dukaew N, et, al. Inactivation of AKT/NF κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncol Rep. 2020 Oct;44(4):1441-1454. DOI:10.3892/or.2020.7710
[3] Malainer C, et, al. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. J Nat Prod. 2017 Dec 22;80(12):3186-3193. DOI:10.1021/acs.jnatprod.7b00503 |
| | EURYCOMALACTONE(P) Preparation Products And Raw materials |
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