| 中文名称 | 2-PCCA(hydrochloride) |
|---|---|
| 中文同义词 | |
| 英文名称 | 2-PCCA(hydrochloride) |
| 英文同义词 | 2-PCCA(hydrochloride) |
| CAS号 | |
| 分子式 | C??H??Cl?N?O? |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
2-PCCA(hydrochloride) 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 白色至浅黄色 |
2-PCCA hydrochloride 是一种外消旋体，为 GPR88 受体激动剂，在 HEK293 细胞中，可抑制 GPR88 介导的 cAMP 的产生，EC50 值为 116 nM。
EC50: 116 nM (GPR88 receptor, HEK293 cells)
2-PCCA hydrochloride inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC 50 of 116 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct.
2-PCCA (0.1-3.2 mg/kg, i.p.) decreases the locomotor activity in rats in a dose-dependent manner in rats. 2-PCCA combined with 1.0 mg/kg methamphetamine also dose-dependently reduces methamphetamine-induced hyperactivity. 2-PCCA (1-3.2 mg/kg, i.p.) alone does not produce methamphetamine-like discriminative stimulus effects, or alter the discriminative stimulus effects of methamphetamine, when studied in combination.