Buflomedil

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Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:buflomedil
CAS:55837-25-7
Purity:0.99 Package:1kg
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Buflomedil;Buflomedilum
CAS:55837-25-7
Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
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Products Intro: Product Name:buflomedil
CAS:55837-25-7
Company Name: AFINE CHEMICALS LIMITED
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Products Intro: Product Name:1-BUTANONE,4-(1-PYRROLIDINYL)-1-(2,4,6-TRIMETHOXYPHENYL)
CAS:55837-25-7
Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier
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Products Intro: Product Name:Buflomedil
CAS:55837-25-7
Purity:98% Package:1g,10g,25g,500g,1kg
Buflomedil Basic information
Product Name:Buflomedil
Synonyms:1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-;2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone;4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon;AURORA KA-850;BUFLOMEDIL;BufluomedilHcl;Buflomedil Hcl 35543-24-9 / Base;Buflomedil (base and/or unspecified salts)
CAS:55837-25-7
MF:C17H25NO4
MW:307.38
EINECS:259-851-3
Product Categories:API;Adrenoceptor;Pharmaceutical;Active Pharmaceutical Ingredients
Mol File:55837-25-7.mol
Buflomedil Structure
Buflomedil Chemical Properties
Boiling point 454.5±45.0 °C(Predicted)
density 1.090±0.06 g/cm3(Predicted)
pka10.15±0.20(Predicted)
LogP3.131 (est)
CAS DataBase Reference55837-25-7(CAS DataBase Reference)
NIST Chemistry ReferenceBuflomedil(55837-25-7)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS EL9885000
HS Code 29339990
MSDS Information
Buflomedil Usage And Synthesis
OriginatorFonzylane,Lafon,France,1976
UsesBAN; DCF; MI.
DefinitionChEBI: 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone is an aromatic ketone.
Manufacturing ProcessIntroduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid bubbler and condenser. Stir to dissolve and add 27.7 g of 4- pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about 5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again with 150 cm3 of water. Combine the aqueous layers, drive off the traces of chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one hour. Cool and render alkaline by means of 60 ml of sodium hydroxide solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50 ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter, wash with ether and dry in a vacuum oven. 33.6 g of crude product are obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA carbon black. Filter. Wash and dry in a vacuum oven.
26.9 g of a white, crystalline water-soluble powder are obtained. Yield: 39.2%. Instantaneous melting point: 192°-193°C.
Therapeutic FunctionVasodilator
Buflomedil Preparation Products And Raw materials
Raw materialsPyrrolidine-->4-Chlorobutyronitrile-->1,3,5-Trimethoxybenzene
Tag:Buflomedil(55837-25-7) Related Product Information
Anisole 3-Methoxybenzaldehyde (Trifluoromethoxy)benzene Prostaglandin E1 p-Anisaldehyde Diltiazem Diltiazem hydrochloride 4-Methoxyphenylacetic acid p-Anisidine 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil 4-Methoxyphenylacetone 4-Methoxybenzylchloride BufloMedil iMpurity (o-desMethyl) BufloMedil Related IMpurity BUFLOMEDIL IMPURITY B Buflomedil pyridoxal phosphate 1-PYRROLIDINOBUTYRONITRILE(BUFLOMEDIL INTERMEDIATE) 2-Butanone