NIGRANOIC ACID
| 中文名称 | NIGRANOIC ACID |
|---|---|
| 中文同义词 | 黑五味子酸 |
| 英文名称 | NIGRANOIC ACID |
| 英文同义词 | NIGRANOIC ACID;(3S,3aR,4aS,6aR,7R,9aS,9bS)-7-[(1R,4Z)-5-Carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-1H-cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid;1H-Cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid, 7-[(1R,4Z)-5-carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-, (3S,3aR,4aS,6aR,7R,9aS,9bS)- |
| CAS号 | 39111-07-4 |
| 分子式 | C30H46O4 |
| 分子量 | 470.69 |
| EINECS号 | |
| 相关类别 | 中药对照品 |
| Mol文件 | Mol File |
| 结构式 |  |
NIGRANOIC ACID 性质
| 熔点 | 128-130 °C |
|---|---|
| 沸点 | 603.0±28.0 °C(Predicted) |
| 密度 | 1.10±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 4.78±0.10(Predicted) |
| 颜色 | 米白色至浅黄色 |
Nigranoic acid 是五味子中分离得到的一种三萜类化合物。Nigranoic acid 能抑制 HIV-1 逆转录酶。在脑缺血再灌注动物模型中，Nigranoic acid 通过 PARP/AIF 信号通路保护大脑。
HIV-1 reverse transcriptase
Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation.
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
| Animal Model: | Sprague–Dawley rats (200-300 g), ischemia–reperfusion model |
| Dosage: | 1 mg/kg |
| Administration: | Intragastric; 6 hours and 2 hours before brain ischemia |
| Result: | Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-122935 | Nigranoic acid | 1 mg | 2600元 | |
| 2024/08/19 | HY-122935 | NIGRANOIC ACID Nigranoic acid | 39111-07-4 | 5mg | 6500元 |