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((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE

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Products Intro: Product Name:4-Iodobut-3-en-2-yl(trimethyl)silane
CAS:52685-51-5
Purity:0.95 Package:1g;10g;100g;1kg
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((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE Basic information
Product Name:((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE
Synonyms:((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE;4-Iodobut-3-en-2-yl(trimethyl)silane;Silane, [(1E)-3-iodo-1-methyl-1-propen-1-yl]trimethyl-
CAS:52685-51-5
MF:C7H15ISi
MW:254.18
EINECS:
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Mol File:52685-51-5.mol
((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE Structure
((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE Chemical Properties
Boiling point 188.9±23.0 °C(Predicted)
density 1.323±0.06 g/cm3(Predicted)
solubility freely sol organic solvents.
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MSDS Information
((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE Usage And Synthesis
Physical propertiesbp 60 °C/20 mmHg.
Uses(E)-1-Iodo-3-trimethylsilyl-2-butene can be used as annulation reagent; alkylative equivalent of 3-buten-2-one; 3-ketobutyl synthon.
Preparationthe first reported preparation of this reagent lacked full experimental details. The preparation given is a compilation of thework of several groups; the various steps have been selected to give optimum yields. 2-Propyn-1-ol is converted3 into its 3-(trimethylsilyl) derivative (1), which is then reduced4 using sodium bis(2-methoxyethoxy)aluminum hydride (Red-Al). The intermediate vinylaluminum is reacted with iodine to produce the (Z)-iodoalkene (2). Treatment of this with lithium dimethylcuprate gives the allylic alcohol (3);. transformation into (E)-(3-chloro-1-methyl-1-propenyl)trimethylsilane (4) followed by halogen exchange with sodium iodide then gives reagent (5).

52685-51-5 synthesis

((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE Preparation Products And Raw materials
Tag:((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE(52685-51-5) Related Product Information
((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE 2-PROPENYLTRIMETHYLSILANE ALLYL IODIDE