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| | PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE Basic information |
| Product Name: | PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE | | Synonyms: | PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE;2,4-Diamino-6-pyrrolidinopyrimidine 3-oxide;6-(1-Pyrrolidinyl)-2,4-pyrimidinediamine 3-oxide;6-(pyrrolidin-1-yl)pyrimidine-2,4-diamine 3-oxide;2,4-PyriMidinediaMine,6-(1-pyrrolidinyl)-, 3-oxide;3-oxy-6-pyrrolidin-1-yl-pyrimidine-2,4-diamine;PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE ISO 9001：2015 REACH;TIANFU-CHEM - PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE | | CAS: | 55921-65-8 | | MF: | C8H13N5O | | MW: | 195.22 | | EINECS: | 618-347-7 | | Product Categories: | | | Mol File: | 55921-65-8.mol |  |
| | PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE Chemical Properties |
| Melting point | 278℃ (DEC.) | | Boiling point | 549.3±60.0 °C(Predicted) | | density | 1.60 | | storage temp. | 2-8°C(protect from light) | | pka | 4.89±0.10(Predicted) |
| | PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE Usage And Synthesis |
| Uses | Pyrrolidinyl Diaminopyrimidine Oxide is a hair growth stimulant that can be used to treat hair loss. It can also be used in cosmetics to invent a dermocosmetic composition having a whitening or dark circle removal or anti-glare effect by containing a pyrrolidinyl diaminopyrimidine oxide compound as an active ingredient. | | Synthesis | Pyrrolidinyl Diaminopyrimidine Oxide is prepared by the reaction of pyrrolidine and 2,6-diamino-4-chloro-pyrimidine N-oxide. The steps are as follows:
Pyrrolidine (7.47 g, 0.105 mol) and 2,6-diamino-4-chloropyrimidine N-oxide (16 g, 0.1 mol) were added to 100 mL ethanol solution, 10% NaOH (0.11 mol) was added dropwise under stirring, and then the reaction was carried out at 80 °C for 120 min. The progress of the reaction was monitored by high performance liquid chromatography. After the reaction is completed, it is cooled to below 5°C, the solvent is removed by filtration, the obtained solid product is washed with water, and recrystallized with hot water to obtain 2,6-diamino-4-pyrrolidinopyrimidine N-oxide as a colorless crystalline solid. Yield 92% (17.96 g), white crystalline powder, mp 276-278°C. IR spectrum (neat), νmax, cm-1: 1195 (C-N), 1346 (C-C), 1463 (N-O), 1613 (C=N), 1651 (C=C), 2856 (C-H), 3265 (C-H), 3298 (O-H), 3428 (N-H). 1H NMR spectrum (500 MHz, DMSO), δ, ppm: 1.87 s (4H, CH2), 3.25 s (4H, N-CH2), 5.08 s (1H, Ar-H), 6.78 s (4H, NH2). 13C NMR spectrum (101 MHz, DMSO), δC, ppm: 26.81, 48.05, 74.81, 153.85, 154.47, 154.60.
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| | PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE Preparation Products And Raw materials |
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