模拟肽CROSSTIDE
| 中文名称 | 模拟肽CROSSTIDE |
|---|---|
| 中文同义词 | 模拟肽CROSSTIDE;(6S,9S,12S,15S,18S,21S,24S)-1-氨基-6-((S)-1-((S)-2-(2-氨基乙酰胺基)-5-胍基戊酰基)吡咯烷-2-甲酰胺基)-18-苄基-24-(2-羧基乙基)-9-((R)-1-羟基乙基)-12,15-双(羟甲基)-1-亚氨基-21-甲基-7,10,13,16,19,22,25-七氧代-2,8,11,14,17,20,23,26-八氮杂二十八N-28-酸 |
| 英文名称 | CROSSTIDE |
| 英文同义词 | Glycine, glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-a-glutaMyl-;Glycine, glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-α-glutamyl-;Crosstide >=97% (HPLC), lyophilized powder;(6S,9S,12S,15S,18S,21S,24S)-1-amino-6-((S)-1-((S)-2-(2-aminoacetamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-18-benzyl-24-(2-carboxyethyl)-9-((R)-1-hydroxyethyl)-12,15-bis(hydroxymethyl)-1-imino-21-methyl-7,10,13,16,19,22,25-heptaoxo-2,8,11,14,17,20,23,26-octaazaoctacosan-28-oic acid |
| CAS号 | 171783-05-4 |
| 分子式 | C48H77N17O17 |
| 分子量 | 1164.23 |
| EINECS号 | |
| 相关类别 | Protein Kinase B (Akt/PKB)Peptides for Cell Biology;Protein Kinase Related Peptides;Protein Kinase Substrates;Serine/Threonine Kinase Biology;Serine/Threonine Kinase Substrates |
| Mol文件 | 171783-05-4.mol |
| 结构式 |  |
模拟肽CROSSTIDE 性质
| 储存条件 | −20°C |
|---|---|
| 溶解度 | 在水中可溶 |
| 形态 | 冻干粉 |
| 颜色 | 白色至米白色 |
Crosstide 是一种糖原合成酶激酶α/β融合蛋白序列的模拟肽，是 Akt 的底物。
|
Akt
|
16HBE14o− cells exposed to RV39 demonstrate a crosstide kinase activity in vitro. Serine phosphorylation of crosstide is confirmed by immunoblotting, and phosphorylation is blocked by PP2 but not by PP3. The wildtype GST-AKT2 shows significant phosphoryl transferase activity towards crosstide, reaching an initial velocity of 16 pmol phosphate/min/μg enzyme. The mutant GST-AKT2T/E,S/D displayed an initial velocity of 85 pmol phosphate/min/μg kinase for phosphorylation of Crosstide, corresponding to a 5-fold increase compared to the wildtype enzyme.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |