Company Name: |
Gihi Chemicals Co., Limited
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Tel: |
+86-0571-86217390 +8618058761490 |
Email: |
info@gihichem.com |
Products Intro: |
Product Name:Sevelamer CAS:52757-95-6 Purity:0.98 Package:100g;500g;1kg;5kg;25kg;Customized by customer
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| Sevelamer Basic information |
Product Name: | Sevelamer | Synonyms: | Sevelamer;2-Propen-1-amine, polymer with (chloromethyl)oxirane;Allylamine polymer with 1-chloro-2,3-epoxypropane;Allylamine-epichlorohydrin copolymer;Hsdb 7608;Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine;Sevelamer [inn:ban];Epichlorohydrin-PAA 25 copolymer | CAS: | 52757-95-6 | MF: | C6H12ClNO | MW: | 149.62 | EINECS: | | Product Categories: | | Mol File: | 52757-95-6.mol | ![Sevelamer Structure](CAS/20180906/GIF/52757-95-6.gif) |
| Sevelamer Chemical Properties |
storage temp. | Store at -20°C | solubility | Soluble in DMSO |
| Sevelamer Usage And Synthesis |
Uses | Antihyper-phosphatemic. | Brand name | Renagel (Genzyme). | Pharmaceutical Applications | In patients on dialysis, Sevelamer or lanthanum salts can be used to maintain normal phosphate blood levels. Sevelamer is a polymer containing amine
groups. These protonated amine groups can react with the negatively charged phosphate groups via ionic binding
and prevent absorption of phosphate from the gut. Sevelamer is a hydrogel containing cross-linked polyallylamine chains. The negatively charged phosphate can be bound to the positively charged amine groups of the hydrogel in the intestines and removed via the faeces. | Clinical Use | Phosphate-binding agent | Drug interactions | Potentially hazardous interactions with other drugs
Antibacterials: reduces bioavailability of
ciprofloxacin.
Ciclosporin: possibly reduces ciclosporin
concentration.
Calcitriol: absorption may be impaired by sevelamer.
Mycophenolate: may reduce mycophenolate levels.
Tacrolimus: possibly reduces tacrolimus
concentration.
Thyroid hormones: possibly reduces levothyroxine
concentration. | Metabolism | Sevelamer is not systemically absorbed. |
| Sevelamer Preparation Products And Raw materials |
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