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Lynnchem
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Product Name:2-(Diphosphonomethyl) butanedioic acid
CAS:51395-42-7
Purity:min. 98 % (31P-NMR) Package:500mg 1g 5g 50g
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CHG Opto-Electronic Corporation Limited
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2537653158 16621191650 |
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Product Name:2-(Diphosphonomethyl) butanedioic acid
CAS:51395-42-7
Purity:min. 98 % (31P-NMR) Package:5KG;1KG;100G;
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TCI (Shanghai) Chemical Trading Co., Ltd.
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021-021-61109150 |
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sales@tcisct.com |
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Product Name:2-(diphosphonomethyl)butanedioic acid
CAS:51395-42-7
Package:1KG;10KG;100KG; Remarks: 纯度：根据客户需求提供
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Leancare Ltd.
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+33 962096793 |
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| | Butedronic acid Basic information |
| Product Name: | Butedronic acid | | Synonyms: | Butedronic acid;Butedronic;(diphosphonomethyl)-Butanedioic acid;2-(diphosphonomethyl)succinic acid;2-(diphosphonomethyl)butanedioic acid;Butanedioic acid, 2-(diphosphonomethyl)- | | CAS: | 51395-42-7 | | MF: | C5H10O10P2 | | MW: | 292.07 | | EINECS: | 403-070-4 | | Product Categories: | | | Mol File: | 51395-42-7.mol |  |
| | Butedronic acid Chemical Properties |
| Melting point | 149.5 °C | | Boiling point | 701.4±70.0 °C(Predicted) | | density | 2.095±0.06 g/cm3(Predicted) | | pka | 0.38±0.10(Predicted) |
| | Butedronic acid Usage And Synthesis |
| Originator | Butedronic acid,Bayer A.G. | | Definition | ChEBI: Butedronic acid is a 1,1-bis(phosphonic acid). | | Manufacturing Process | 0.5 mole of methylene diphosphonic acid tetraethyl ester is heated for 6 h to
110°C with 0.5 mole of maleic acid diethyl ester in the presence of 25 ml of a
saturated sodium ethylate solution. The sodium ethylate is then neutralized
with acetic acid and the reaction mixture is quickly distilled invacuo in order to
avoid decomposition. The crude distillate is redistillated, the main fraction
accumulating in the range from 190-213°C at a pressure of 0.05 Torr, yield
50%.
The ester is hydrolyzed by boiling with concentrated hydrochloric acid. 1,1-
Diphosphonopropane-2,3-dicarboxylic acid crystallizes out after purification
with active carbon and concentration of the hydrolysis product, yield 100%. | | Therapeutic Function | Diagnostic aid |
| | Butedronic acid Preparation Products And Raw materials |
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