Arg-Gly-Asp-Ser
| 中文名称 | Arg-Gly-Asp-Ser |
|---|---|
| 中文同义词 | 精氨酰-甘氨酰-天冬氨酰-丝氨酸;精氨酸-甘氨酸-天冬氨酸-丝氨酸;甘氨酸-天冬氨酸;L-精氨酰甘氨酰-L-ALPHA-天冬氨酰-L-丝氨酸;天冬氨酸精氨酸;精氨酰-甘氨酰-天冬氨酰-丝氨酸, ≥95%(HPLC);精-甘-天冬-丝氨酸;(6S,12S,15S)-1,6-二氨基-12-(羧甲基)-15-(羟甲基)-1-亚氨基-7,10,13-三氧代-2,8,11,14-四氮杂十六烷-16-羧酸 |
| 英文名称 | ARG-GLY-ASP-SER |
| 英文同义词 | Fibronectin tetrapeptide;L-Arginylglycyl-L-alpha-aspartyl-L-serine;L-Serine, L-arginylglycyl-L-alpha-aspartyl-;L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-aspartyl)-;arginyl-glycyl-aspartyl-serine;RGDS;RGDS 1/2ACOH 2H2O;L-Serine,N-[N-(N-L-arginylglycyl)-L-a-aspartyl]- |
| CAS号 | 91037-65-9 |
| 分子式 | C15H27N7O8 |
| 分子量 | 433.42 |
| EINECS号 | 1592732-453-0 |
| 相关类别 | 细胞生物学;肽;细胞信号和神经生物学;多肽;标准品;Peptide;Cell Signaling Enzymes;ECM ProteinsCytoskeleton and Extracellular Matrix;Extracellular Matrix;Extracellular Matrix Peptides (ECM);Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology;Fibronectin Fragments and Analogs;Matrix Metalloproteinases Products;Various Peptides;RGD |
| Mol文件 | 91037-65-9.mol |
| 结构式 |  |
Arg-Gly-Asp-Ser 性质
| 熔点 | 183-187℃ |
|---|---|
| 密度 | 1.65±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 水中≥21.65 mg/mL；不溶于乙醇；不溶于DMSO |
| 形态 | 白色至类白色粉末 |
| 酸度系数(pKa) | 2.84±0.10(Predicted) |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble in water at 1mg/ml |
| 序列 | H-Arg-Gly-Asp-Ser-OH |
The Arg-Gly-Asp-Ser-modified surface causes up-regulation of αvβ3 integrin. Attachment to the Arg-Gly-Asp-Ser-treated membrane completely abolishes apoptosis induced by staurosporine, the Ca 2+ ·Pi ion pair, and sodium nitroprusside. Arg-Gly-Asp-Ser-dependent resistance to apoptosis is eliminated, when the activity of the phosphatidylinositol 3-kinase pathway is inhibited. Arg-Gly-Asp-Ser interacts with survivin, as well as with procaspase-3, -8 and -9. Arg-Gly-Asp-Ser-peptide binding to survivin is found to be specific, at high affinity (K d 27.5 μM) and locates at the survivin C-terminus. Arg-Gly-Asp-Ser-survivin interaction appears to play a key role, since Arg-Gly-Asp-Ser lost its anti-mitogenic effect in survivin-deprived cells with a specific siRNA.
Arg-Gly-Asp-Ser (2.5 or 5 mg/kg, 1 h before LPS) significantly inhibits LPS-induced MMP-9 activity in BAL fluid 4 h post-LPS. Arg-Gly-Asp-Ser (1, 2.5 or 5 mg/kg, i.p.) administers 1 h before LPS inhibited LPS-induced increases in TNF-α and MIP-2 levels in BAL fluid at 4 h post-LPS. Arg-Gly-Asp-Ser peptide significantly reduces tumor necrosis factor (TNF)-α and macrophage inflammatory protein (MIP)-2 production, and decreases myeloperoxidase (MPO) and NF-κB activity.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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