8-羟基-1,3,6-萘三磺酸三钠盐
| 中文名称 | 8-羟基-1,3,6-萘三磺酸三钠盐 |
|---|---|
| 中文同义词 | 8-羟基-1,3,6-萘三磺酸三钠盐;1-萘酚-3,6,8-三磺酸三钠盐 |
| 英文名称 | 1-NAPHTHOL-3,6,8-TRISULFONIC ACID TRISODIUM SALT |
| 英文同义词 | 1-NAPHTHOL-3,6,8-TRISULFONIC ACID TRISODIUM SALT;1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-, trisodium salt;Zeta-Stat trisodium;ζ-Stat trisodium;NSC37044 trisodium |
| CAS号 | 31894-34-5 |
| 分子式 | C10H5Na3O10S3 |
| 分子量 | 450.31 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 31894-34-5.mol |
| 结构式 |  |
8-羟基-1,3,6-萘三磺酸三钠盐 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 浅黄至浅棕色 |
|
aPKC-ζ 5 μM (IC 50 ) |
ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level.
ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations.
ζ-Stat (7 or 10 µM; 24-72 h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%.
ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells.
ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells.
Cell Proliferation Assay
| Cell Line: | MEL-F-NEO, SK-MEL-2 and MeWo cells |
| Concentration: | 0.1, 0.5, 1, 2.5, 5, 7.5, 10 µM |
| Incubation Time: | 3 days |
| Result: |
Decreased proliferation by 47.7% for 5 µM in SK-MEL-2 cells and by 50.6% for 5 µM in MeWo cells.
Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM. |
Western Blot Analysis
| Cell Line: | SK-MEL-2 and MeWo cells |
| Concentration: | 5 µM |
| Incubation Time: | 3 days |
| Result: | Decreased phosphorylated and total PKC-ζ levels. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-123979A | ζ-Stat trisodium | 1 mg | 1200元 | |
| 2024/04/30 | HY-123979A | 8-羟基-1,3,6-萘三磺酸三钠盐 ζ-Stat trisodium | 31894-34-5 | 5mg | 3000元 |