Company Name: |
Zhejiang Huida Biotech Co., LTD
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Tel: |
0571-89903882 13626641628 |
Email: |
jiangnan@huidabiotech.com |
Products Intro: |
Product Name:Holomycin CAS:488-04-0 Purity:99% HPLC Package:10mg;100mg;1g;10g;100g
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Company Name: |
Energy Chemical
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Tel: |
021-58432009 400-005-6266 |
Email: |
marketing@energy-chemical.com |
Products Intro: |
Product Name:Holomycin CAS:488-04-0 Purity:NULL Package:2.5mg;25mg Remarks:NULL
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Company Name: |
Zhejiang Huida Biotech Co., LTD
|
Tel: |
0571-0571-89903882 15990081639 |
Email: |
sunshixuan@huidabiotech.com |
Products Intro: |
Product Name:Holomycin CAS:488-04-0 Purity:99% HPLC Package:10mg;100mg;1g;10g;100g
|
|
| holomycin Basic information |
Product Name: | holomycin | Synonyms: | holomycin;N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide;N-Demethylthiolutin;N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide;Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)- | CAS: | 488-04-0 | MF: | C7H6N2O2S2 | MW: | 214.26 | EINECS: | | Product Categories: | | Mol File: | 488-04-0.mol | |
| holomycin Chemical Properties |
Melting point | 268 °C (decomp) | Boiling point | 532.1±50.0 °C(Predicted) | density | 1.63±0.1 g/cm3(Predicted) | solubility | DMSO, Methanol (Heated) | form | Solid | pka | 9.33±0.40(Predicted) | color | Brown-Orange |
Toxicity | LD50 i.v. in mice: 5-10 mg/kg (Von Daehne) |
| holomycin Usage And Synthesis |
Uses | Holomycin-d3 is the isotope labelled analog of Holomycin (H458490); a member of the pyrrothine class of antibiotics that displays broad-spectrum antibacterial activity. | Definition | ChEBI: Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as a chelator, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, an antibacterial agent, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides. | Synthesis Reference(s) | Journal of the American Chemical Society, 86, p. 5654, 1964 DOI: 10.1021/ja01078a049 |
| holomycin Preparation Products And Raw materials |
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