SR 11237
| 中文名称 | SR 11237 |
|---|---|
| 中文同义词 | 化合物 T23383;化合物SR11237;SR 11237,泛RXR激动剂 |
| 英文名称 | SR 11237 |
| 英文同义词 | SR 11237;4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacid;4-(2-(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acid;BMS 188649;BMS649;Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-;Retinoid X receptors,bone,BMS 649,transactivate,BMS649,Retinoic acid receptors,reporter,ossification,RAR/RXR,inhibit,Inhibitor,RXR/RXR,BMS-649,SR11237,homodimers,gene,SR-11237 |
| CAS号 | 146670-40-8 |
| 分子式 | C24H28O4 |
| 分子量 | 380.48 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 146670-40-8.mol |
| 结构式 |  |
SR 11237 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：>28mg/mL（加热） |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
SR11237 (BMS-649) 是一种视黄醇 X 受体 (RXR) 选择性激动剂，没有任何 RAR 活性。SR11237可导致 RXR/RXR 同型二聚体形成并激活含有 RXR 反应元件的报告基因。
Using nuclear receptor co-transfection assays in COS-1 cells, that SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors.
SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate.
| Animal Model: | Sprague-Dawley rats |
| Dosage: | 25 mg/kg |
| Administration: | I.p.; daily from post-natal days 5 to 15 |
| Result: | Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis. |
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-107413 | SR11237 | 1 mg | 1045元 | |
| 2024/04/30 | HY-107413 | SR 11237 SR11237 | 146670-40-8 | 5mg | 2300元 |