- Vorasidenib;AG-881
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- $0.00 / 1g
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2021-10-08
- CAS:1644545-52-7
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 100kgs
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| Product Name: | PVM/MA | | Synonyms: | PF06291874;Vorasidenib;PVM/MA;S-N-NITROSO-2-METHYLPIPERIDINE;PCB138/160;FLEABUSTERSRXPOWDER;15-HYDROPEROXYEICOSATETRAENOICACID;CALCIUM(C10-C16)ALKYLBENZENESULPHONATE | | CAS: | 1644545-52-7 | | MF: | C14H13ClF6N6 | | MW: | 414.74 | | EINECS: | | | Product Categories: | Dimethoxyamphetamine;api | | Mol File: | 1644545-52-7.mol |  |
| | PVM/MA Chemical Properties |
| Boiling point | 467.5±55.0 °C(Predicted) | | density | 1.491±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml | | form | A crystalline solid | | pka | 1.49±0.41(Predicted) | | color | Light yellow to light brown |
| | PVM/MA Usage And Synthesis |
| Uses | PF-06291874 is a novel and potent glucagon receptor antagonist for the potential treatment of diabetes mellitus. PF-06291874, has a lower molcular weight and lipophilicity than historical glucagon receptor antagonists, resulting in excellent selectivity in broad-panel screening, lower cytotoxicity, and excellent overall in vivo safety in early pre-clinical testing. | | Synthesis | Maleic anhydride (MA) was added to a solvent mixture of cyclohexane and ethyl acetate in a polymerizer equipped with an agitator, a reflux condenser, and an inner temperature-controlling device. The polymerizer was purged of air and filled with nitrogen. The solution was heated to 70 °C, and then an initiator solution (lauroyl peroxide dissolved in ethyl acetate) and Methyl vinyl ether (MVE) were added to the polymerizer in a dropwise manner. A slurry was obtained, which was filtered and dried under a vacuum to obtain a white powdery copolymer. |
| | PVM/MA Preparation Products And Raw materials |
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