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| | Platelet Activating Factor-16 Basic information |
| Product Name: | Platelet Activating Factor-16 | | Synonyms: | L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-ACETYL-GAMMA-O-HEXADECYL;L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-ACETYL-GAMMA-O-ALKYL;C16-02:0 PC;C16PAF;C16 ENANTIOMERIC PAF;1-O-AKYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE;1-O-PALMITYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE;1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE | | CAS: | 74389-68-7 | | MF: | C26H54NO7P | | MW: | 523.68 | | EINECS: | | | Product Categories: | | | Mol File: | 74389-68-7.mol |  |
| | Platelet Activating Factor-16 Chemical Properties |
| Melting point | 247 °C | | storage temp. | -20°C | | solubility | Soluble in H2O or ethanol | | form | lyophilized powder | | color | White to off-white | | Water Solubility | Soluble to 100 mM in water | | BRN | 3574588 |
| | Platelet Activating Factor-16 Usage And Synthesis |
| Uses | PAF (C16) (cas# 74389-68-7) is a blood platelet-activating factor, used to study human airway smooth muscle cell line. | | Uses | C16-02:0 PC or 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine may be used as a substrate in enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay. It may also be used to study its physicochemical properties and its interaction with peptides derived from the C-terminal domains of human apolipoprotein E. | | Definition | ChEBI: A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis. | | General Description | C16-02:0 PC, also known as 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16 PAF) (acetyl PAF), is a platelet-activating factor (PAF). Acetyl PAF is present in the body and it contains ether-linked hexadecyl chain at the sn-1 position and an acetyl group at the sn-2 position. | | Biological Activity | Endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability. | | Biochem/physiol Actions | Platelet-activating factor (PAF) is a pro-inflammatory agent that exhibits variety of biological and pharmacological effects. It plays a major role in initiation and progression of atherosclerosis. PAF acts as a potential biomarker for coronary artery diseases. It yields LysoPAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine) on hydrolysis by platelet-activating factor-acetylhydrolase. | | storage | Store at -20°C |
| | Platelet Activating Factor-16 Preparation Products And Raw materials |
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